{
  "annotation_id": "ffae069a-bb55-438b-a520-d3e05a2e5c6e",
  "date_created": "2026-03-02T18:01:31.346000Z",
  "date_modified": "2026-03-02T18:01:31.346000Z",
  "file_hash": "153c05df2b789b0301f0fc313d579487790a39cdf49b77f07adcb99569cd2978",
  "private": false,
  "record": {
    "abstract": "This paper describes a Bayesian statistical method for determining the\ngenetic basis of a complex genetic trait. The method uses a sample of unrelated\nindividuals classified into two groups, for example cases and controls. Each\ngroup is assumed to have been genotyped at a battery of marker loci using a\nlaboratory effort efficient technique called DNA pooling. The aim is to detect\nand map a quantitative trait locus (QTL) that is not one of the typed markers.\nThe method works by conducting an exact Bayesian analysis under a number of\nsimplifying population genetic assumptions that are somewhat unrealistic.\nDespite this, the method is shown to perform acceptably on datasets simulated\nunder a more realistic model, and furthermore is shown to outperform classical\nsingle point methods.",
    "arxiv_id": "q-bio/0507018",
    "authors": [
      "Toby Johnson"
    ],
    "categories": [
      "q-bio.GN",
      "q-bio.PE",
      "q-bio.QM"
    ],
    "doi": "10.1093/biostatistics/kxl028",
    "journal_ref": "Biostatistics (2007) 8:546--565",
    "title": "Bayesian Method for Disease QTL Detection and Mapping, using a Case and   Control Design and DNA Pooling",
    "url": "https://arxiv.org/abs/q-bio/0507018"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a1d9d65e-3abf-464b-801c-fb82aaf7c1ed",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}