dorsal/arxiv
View SchemaBayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling
| Authors | Toby Johnson |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0507018 |
| URL | https://arxiv.org/abs/q-bio/0507018 |
| DOI | 10.1093/biostatistics/kxl028 |
| Journal | Biostatistics (2007) 8:546--565 |
Abstract
This paper describes a Bayesian statistical method for determining the genetic basis of a complex genetic trait. The method uses a sample of unrelated individuals classified into two groups, for example cases and controls. Each group is assumed to have been genotyped at a battery of marker loci using a laboratory effort efficient technique called DNA pooling. The aim is to detect and map a quantitative trait locus (QTL) that is not one of the typed markers. The method works by conducting an exact Bayesian analysis under a number of simplifying population genetic assumptions that are somewhat unrealistic. Despite this, the method is shown to perform acceptably on datasets simulated under a more realistic model, and furthermore is shown to outperform classical single point methods.
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"abstract": "This paper describes a Bayesian statistical method for determining the\ngenetic basis of a complex genetic trait. The method uses a sample of unrelated\nindividuals classified into two groups, for example cases and controls. Each\ngroup is assumed to have been genotyped at a battery of marker loci using a\nlaboratory effort efficient technique called DNA pooling. The aim is to detect\nand map a quantitative trait locus (QTL) that is not one of the typed markers.\nThe method works by conducting an exact Bayesian analysis under a number of\nsimplifying population genetic assumptions that are somewhat unrealistic.\nDespite this, the method is shown to perform acceptably on datasets simulated\nunder a more realistic model, and furthermore is shown to outperform classical\nsingle point methods.",
"arxiv_id": "q-bio/0507018",
"authors": [
"Toby Johnson"
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"doi": "10.1093/biostatistics/kxl028",
"journal_ref": "Biostatistics (2007) 8:546--565",
"title": "Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling",
"url": "https://arxiv.org/abs/q-bio/0507018"
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