dorsal/arxiv
View SchemaModeling stochastic gene expression under repression
| Authors | Guilherme da C. P. Innocentini, Jose E. M. Hornos |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0512016 |
| URL | https://arxiv.org/abs/q-bio/0512016 |
Abstract
Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple spin like stochastic model. The effects of transcriptional fluctuations in protein synthesis is probed by coupling transcription and translation by an amplificative interaction. In the presence of repression a new term contributes to the noise which depends on the rate of mRNA production. If the switching time is small compared with the mRNA life time the noise is also small. In general the dumping of protein production by a repressive agent occurs linearly but the fluctuations can show a maxima at intermediate repression. The discrepancy between the switching time, the mRNA degradation and protein degradation is crucial for the repressive control in translation without large fluctuations. The noise profiles obtained here are in quantitative agreement with recent experiments.
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"abstract": "Intrinsic transcriptional noise induced by operator fluctuations is\ninvestigated with a simple spin like stochastic model. The effects of\ntranscriptional fluctuations in protein synthesis is probed by coupling\ntranscription and translation by an amplificative interaction. In the presence\nof repression a new term contributes to the noise which depends on the rate of\nmRNA production. If the switching time is small compared with the mRNA life\ntime the noise is also small. In general the dumping of protein production by a\nrepressive agent occurs linearly but the fluctuations can show a maxima at\nintermediate repression. The discrepancy between the switching time, the mRNA\ndegradation and protein degradation is crucial for the repressive control in\ntranslation without large fluctuations. The noise profiles obtained here are in\nquantitative agreement with recent experiments.",
"arxiv_id": "q-bio/0512016",
"authors": [
"Guilherme da C. P. Innocentini",
"Jose E. M. Hornos"
],
"categories": [
"q-bio.OT"
],
"title": "Modeling stochastic gene expression under repression",
"url": "https://arxiv.org/abs/q-bio/0512016"
},
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