dorsal/arxiv
View SchemaDNA properties investigated by dynamic force microscopy
| Authors | Laurent Nony, Rodolphe Boisgard, Jean-Pierre Aimé |
|---|---|
| Categories | |
| ArXiv ID | physics/0510093 |
| URL | https://arxiv.org/abs/physics/0510093 |
| Journal | Biomacromolecules 2 (2001) 827-835 |
Abstract
In this work, we show that by varying the experimental conditions, the driving amplitude, a dynamic force microscope allows DNA properties to be selectively imaged. The substrate on which the DNA is fixed is a silica surface grafted with silanes molecules ended with amine groups. Use of small oscillation amplitudes favors the attractive interaction between the tip and the sample, while use of large amplitudes renders the contribution of the attractive interaction negligible. Particularly, at small amplitudes, the images show that the attractive interaction is strongly enhanced along the DNA. This enhancement is found to be amenable with a model considering a narrow strip of randomly oriented dipoles on each side of the molecule. This work should provide new insights on the DNA interaction and conformational changes with localized charges.
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"abstract": "In this work, we show that by varying the experimental conditions, the\ndriving amplitude, a dynamic force microscope allows DNA properties to be\nselectively imaged. The substrate on which the DNA is fixed is a silica surface\ngrafted with silanes molecules ended with amine groups. Use of small\noscillation amplitudes favors the attractive interaction between the tip and\nthe sample, while use of large amplitudes renders the contribution of the\nattractive interaction negligible. Particularly, at small amplitudes, the\nimages show that the attractive interaction is strongly enhanced along the DNA.\nThis enhancement is found to be amenable with a model considering a narrow\nstrip of randomly oriented dipoles on each side of the molecule. This work\nshould provide new insights on the DNA interaction and conformational changes\nwith localized charges.",
"arxiv_id": "physics/0510093",
"authors": [
"Laurent Nony",
"Rodolphe Boisgard",
"Jean-Pierre Aim\u00e9"
],
"categories": [
"physics.bio-ph"
],
"journal_ref": "Biomacromolecules 2 (2001) 827-835",
"title": "DNA properties investigated by dynamic force microscopy",
"url": "https://arxiv.org/abs/physics/0510093"
},
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