dorsal/arxiv
View SchemaGlobal organization of metabolic fluxes in the bacterium, Escherichia coli
| Authors | E. Almaas, B. Kovacs, T. Vicsek, Z. N. Oltvai, A. -L. Barabasi |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0403001 |
| URL | https://arxiv.org/abs/q-bio/0403001 |
| DOI | 10.1038/nature02289 |
| Journal | Nature 427, 839-843 (2004) |
Abstract
Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological organization of individual reactions into metabolic networks is increasingly well understood, the principles governing their global functional utilization under different growth conditions pose many open questions. We implement a flux balance analysis of the E. coli MG1655 metabolism, finding that the network utilization is highly uneven: while most metabolic reactions have small fluxes, the metabolism's activity is dominated by several reactions with very high fluxes. E. coli responds to changes in growth conditions by reorganizing the rates of selected fluxes predominantly within this high flux backbone. The identified behavior likely represents a universal feature of metabolic activity in all cells, with potential implications to metabolic engineering.
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"abstract": "Cellular metabolism, the integrated interconversion of thousands of metabolic\nsubstrates through enzyme-catalyzed biochemical reactions, is the most\ninvestigated complex intercellular web of molecular interactions. While the\ntopological organization of individual reactions into metabolic networks is\nincreasingly well understood, the principles governing their global functional\nutilization under different growth conditions pose many open questions. We\nimplement a flux balance analysis of the E. coli MG1655 metabolism, finding\nthat the network utilization is highly uneven: while most metabolic reactions\nhave small fluxes, the metabolism\u0027s activity is dominated by several reactions\nwith very high fluxes. E. coli responds to changes in growth conditions by\nreorganizing the rates of selected fluxes predominantly within this high flux\nbackbone. The identified behavior likely represents a universal feature of\nmetabolic activity in all cells, with potential implications to metabolic\nengineering.",
"arxiv_id": "q-bio/0403001",
"authors": [
"E. Almaas",
"B. Kovacs",
"T. Vicsek",
"Z. N. Oltvai",
"A. -L. Barabasi"
],
"categories": [
"q-bio.MN",
"cond-mat.dis-nn",
"q-bio.CB"
],
"doi": "10.1038/nature02289",
"journal_ref": "Nature 427, 839-843 (2004)",
"title": "Global organization of metabolic fluxes in the bacterium, Escherichia coli",
"url": "https://arxiv.org/abs/q-bio/0403001"
},
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