dorsal/arxiv
View SchemaThe Bacterial Chemotactic Response Reflects a Compromise Between Transient and Steady State Behavior
| Authors | Damon A. Clark, Lars C. Grant |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0602003 |
| URL | https://arxiv.org/abs/q-bio/0602003 |
| DOI | 10.1073/pnas.0407659102 |
| Journal | Proc. Natl. Acad. Sci. U.S.A., 102, (26): 9150-9155 (2005) |
Abstract
Swimming bacteria detect chemical gradients by performing temporal comparisons of recent measurements of chemical concentration. These comparisons are described quantitatively by the chemotactic response function, which we expect to optimize chemotactic behavioral performance. We identify two independent chemotactic performance criteria: in the short run, a favorable response function should move bacteria up chemoattractant gradients, while in the long run, bacteria should aggregate at peaks of chemoattractant concentration. Surprisingly, these two criteria conflict, so that when one performance criterion is most favorable, the other is unfavorable. Since both types of behavior are biologically relevant, we include both behaviors in a composite optimization that yields a response function that closely resembles experimental measurements. Our work suggests that the bacterial chemotactic response function can be derived from simple behavioral considerations, and sheds light on how the response function contributes to chemotactic performance.
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"abstract": "Swimming bacteria detect chemical gradients by performing temporal\ncomparisons of recent measurements of chemical concentration. These comparisons\nare described quantitatively by the chemotactic response function, which we\nexpect to optimize chemotactic behavioral performance. We identify two\nindependent chemotactic performance criteria: in the short run, a favorable\nresponse function should move bacteria up chemoattractant gradients, while in\nthe long run, bacteria should aggregate at peaks of chemoattractant\nconcentration. Surprisingly, these two criteria conflict, so that when one\nperformance criterion is most favorable, the other is unfavorable. Since both\ntypes of behavior are biologically relevant, we include both behaviors in a\ncomposite optimization that yields a response function that closely resembles\nexperimental measurements. Our work suggests that the bacterial chemotactic\nresponse function can be derived from simple behavioral considerations, and\nsheds light on how the response function contributes to chemotactic\nperformance.",
"arxiv_id": "q-bio/0602003",
"authors": [
"Damon A. Clark",
"Lars C. Grant"
],
"categories": [
"q-bio.CB",
"cond-mat.stat-mech",
"q-bio.PE"
],
"doi": "10.1073/pnas.0407659102",
"journal_ref": "Proc. Natl. Acad. Sci. U.S.A., 102, (26): 9150-9155 (2005)",
"title": "The Bacterial Chemotactic Response Reflects a Compromise Between Transient and Steady State Behavior",
"url": "https://arxiv.org/abs/q-bio/0602003"
},
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