{
  "annotation_id": "fb66d6e5-9fda-4766-9b6c-a97049e9eb49",
  "date_created": "2026-03-02T18:01:00.068000Z",
  "date_modified": "2026-03-02T18:01:00.068000Z",
  "file_hash": "c9f0eac1fe9b05103571813a4c4951a8310c1baf753fa92d0f48ec9ee1062197",
  "private": false,
  "record": {
    "abstract": "In order to grasp the features arising from cellular discreteness and\nindividuality, in large parts of cell tissue modelling agent-based models are\nfavoured. The subclass of off-lattice models allows for a physical motivation\nof the intercellular interaction rules. We apply an improved version of a\npreviously introduced off-lattice agent-based model to the steady-state flow\nequilibrium of skin. The dynamics of cells is determined by conservative and\ndrag forces,supplemented with delta-correlated random forces. Cellular\nadjacency is detected by a weighted Delaunay triangulation. The cell cycle time\nof keratinocytes is controlled by a diffusible substance provided by the\ndermis. Its concentration is calculated from a diffusion equation with\ntime-dependent boundary conditions and varying diffusion coefficients. The\ndynamics of a nutrient is also taken into account by a reaction-diffusion\nequation. It turns out that the analysed control mechanism suffices to explain\nseveral characteristics of epidermal homoeostasis formation. In addition, we\nexamine the question of how {\\em in silico} melanoma with decreased basal\nadhesion manage to persist within the steady-state flow-equilibrium of the\nskin.Interestingly, even for melanocyte cell cycle times being substantially\nshorter than for keratinocytes, tiny stochastic effects can lead to completely\ndifferent outcomes. The results demonstrate that the understanding of initial\nstates of tumour growth can profit significantly from the application of\noff-lattice agent-based models in computer simulations.",
    "arxiv_id": "physics/0507059",
    "authors": [
      "Gernot Schaller",
      "Michael Meyer-Hermann"
    ],
    "categories": [
      "physics.bio-ph"
    ],
    "doi": "10.1016/j.jtbi.2007.03.023",
    "journal_ref": "Journal of Theoretical Biology 247, 554-573, (2007)",
    "title": "A modelling approach towards Epidermal homoeostasis control",
    "url": "https://arxiv.org/abs/physics/0507059"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "45126e21-8687-4dab-93da-a1a871a3a281",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}