dorsal/arxiv
View SchemaConnectivity and expression in protein networks: Proteins in a complex are uniformly expressed
| Authors | Shai Carmi, Erez Y. Levanon, Shlomo Havlin, Eli Eisenberg |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0508021 |
| URL | https://arxiv.org/abs/q-bio/0508021 |
| DOI | 10.1103/PhysRevE.73.031909 |
| Journal | Phys. Rev. E 73, 031909 (2006) |
Abstract
We explore the interplay between the protein-protein interactions network and the expression of the interacting proteins. It is shown that interacting proteins are expressed in significantly more similar cellular concentrations. This is largely due to interacting pairs which are part of protein complexes. We solve a generic model of complex formation and show explicitly that complexes form most efficiently when their members have roughly the same concentrations. Therefore, the observed similarity in interacting protein concentrations could be attributed to optimization for efficiency of complex formation.
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"abstract": "We explore the interplay between the protein-protein interactions network and\nthe expression of the interacting proteins. It is shown that interacting\nproteins are expressed in significantly more similar cellular concentrations.\nThis is largely due to interacting pairs which are part of protein complexes.\nWe solve a generic model of complex formation and show explicitly that\ncomplexes form most efficiently when their members have roughly the same\nconcentrations. Therefore, the observed similarity in interacting protein\nconcentrations could be attributed to optimization for efficiency of complex\nformation.",
"arxiv_id": "q-bio/0508021",
"authors": [
"Shai Carmi",
"Erez Y. Levanon",
"Shlomo Havlin",
"Eli Eisenberg"
],
"categories": [
"q-bio.MN",
"cond-mat.other",
"q-bio.OT"
],
"doi": "10.1103/PhysRevE.73.031909",
"journal_ref": "Phys. Rev. E 73, 031909 (2006)",
"title": "Connectivity and expression in protein networks: Proteins in a complex are uniformly expressed",
"url": "https://arxiv.org/abs/q-bio/0508021"
},
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