{
  "annotation_id": "f8c2679a-6dab-4148-a74e-80bbf044874c",
  "date_created": "2026-03-02T18:01:31.023000Z",
  "date_modified": "2026-03-02T18:01:31.023000Z",
  "file_hash": "09496e2f532c04dfea3c3121923248cb4bfc8521ea1c19c298443faa00db52ec",
  "private": false,
  "record": {
    "abstract": "We show how to incorporate fluctuations of the recombination rate along the chromosome into standard gene-genealogical models for the decorrelation of gene histories. This enables us to determine how small-scale fluctuations (Poissonian hot-spot model) and large-scale variations [Kong et al. (2002)] of the recombination rate influence this decorrelation. We find that the empirically determined large-scale variations of the recombination rate give rise to a significantly slower decay of correlations compared to the standard, unstructured gene-genealogical model assuming constant recombination rate. A model with long-range recombination-rate variations and with demographic structure (divergent population) is found to be consistent with the empirically observed slow decorrelation of gene histories. Conversely, we show that small-scale recombination-rate fluctuations do not alter the large-scale decorrelation of gene histories.",
    "arxiv_id": "q-bio/0404020",
    "authors": [
      "A. Eriksson",
      "B. Mehlig"
    ],
    "categories": [
      "q-bio.PE"
    ],
    "doi": "10.1534/genetics.103.018002",
    "journal_ref": "Genetics 169, 1175-1178 (2005)",
    "title": "On the effect of fluctuating recombination rates on the decorrelation of gene histories in the human genome",
    "url": "https://arxiv.org/abs/q-bio/0404020"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "0211400a-db30-4654-80e2-fcc0101d218c",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}