dorsal/arxiv
View SchemaThe role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model
| Authors | Hervé Henry, Wouter-Jan Rappel |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0407027 |
| URL | https://arxiv.org/abs/q-bio/0407027 |
| DOI | 10.1063/1.1636272 |
| Journal | Chaos Vol 14 pages 172-182 (2004) |
Abstract
In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a description of the long QT 3 syndrome, and is studied in both one dimension, corresponding to a cable traversing the ventricular wall, and two dimensions, representing a transmural slice. We focus on two possible mechanisms for the generation of reentrant events. We first investigate if early-after-depolarizations occurring in M cells can initiate reentry. We find that, even for large values of the long QT strength, the electrotonic coupling between neighboring cells prevents early-after-depolarizations from creating a reentry. We then study whether M cell domains, with their slow repolarization, can function as wave blocks for premature stimuli. We find that the inclusion of an M cell domain can result in some cases in reentrant excitations and we determine the lifetime of the reentry as a function of the size and geometry of the domain and of the strength of the long QT syndrome.
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"abstract": "In this numerical study, we investigate the role of intrinsic heterogeneities\nof cardiac tissue due to M cells in the generation and maintenance of reentrant\nexcitations using the detailed Luo-Rudy dynamic model. This model has been\nextended to include a description of the long QT 3 syndrome, and is studied in\nboth one dimension, corresponding to a cable traversing the ventricular wall,\nand two dimensions, representing a transmural slice. We focus on two possible\nmechanisms for the generation of reentrant events. We first investigate if\nearly-after-depolarizations occurring in M cells can initiate reentry. We find\nthat, even for large values of the long QT strength, the electrotonic coupling\nbetween neighboring cells prevents early-after-depolarizations from creating a\nreentry. We then study whether M cell domains, with their slow repolarization,\ncan function as wave blocks for premature stimuli. We find that the inclusion\nof an M cell domain can result in some cases in reentrant excitations and we\ndetermine the lifetime of the reentry as a function of the size and geometry of\nthe domain and of the strength of the long QT syndrome.",
"arxiv_id": "q-bio/0407027",
"authors": [
"Herv\u00e9 Henry",
"Wouter-Jan Rappel"
],
"categories": [
"q-bio.TO",
"cond-mat.other",
"nlin.PS",
"q-bio.OT"
],
"doi": "10.1063/1.1636272",
"journal_ref": "Chaos Vol 14 pages 172-182 (2004)",
"title": "The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model",
"url": "https://arxiv.org/abs/q-bio/0407027"
},
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