dorsal/arxiv
View SchemaDMSO-Induced Dehydration of DPPC Membranes Studied by X-ray Diffraction, Small-Angle Neutron Scattering, and Calorimetry
| Authors | M. A. Kiselev, P. Lesieur, A. M. Kisselev, C. Grabielle-Madelmond, M. Ollivon |
|---|---|
| Categories | |
| ArXiv ID | physics/0108019 |
| URL | https://arxiv.org/abs/physics/0108019 |
| Journal | Journal of Alloys and Compounds 286 (1999) 195-202 |
Abstract
The influence of dimethyl sulfoxide (DMSO) on membrane thickness, multilamellar repeat distance, and phase transitions of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) was investigated by X-ray diffraction and small-angle neutron scattering (SANS). The differential scanning calorimetry (DSC) study of water freezing and ice melting was performed in the ternary DPPC /DMSO /water and binary DMSO /water systems. The methods applied demonstrated the differences in membrane structure in three sub-regions of the DMSO mole fraction (X_dmso): from 0.0 to 0.3 for the first, from 0.3 to 0.8 for the second, and from 0.9 to 1.0 for the third sub-region. The thickness of the intermembrane solvent at T =20C decreases from 14.4 +/- 1.8 A at X_dmso =0.0 to 7.8 +/- 1.8 A at X_dmso =0.1. The data were used to determine the number of free water molecules in the intermembrane space in the presence of DMSO. The results for 0.0 < X_dmso < 0.3 were explained in the framework of DMSO-induced dehydration of the intermembrane space.
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"abstract": "The influence of dimethyl sulfoxide (DMSO) on membrane thickness,\nmultilamellar repeat distance, and phase transitions of\n1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) was investigated by\nX-ray diffraction and small-angle neutron scattering (SANS). The differential\nscanning calorimetry (DSC) study of water freezing and ice melting was\nperformed in the ternary DPPC /DMSO /water and binary DMSO /water systems. The\nmethods applied demonstrated the differences in membrane structure in three\nsub-regions of the DMSO mole fraction (X_dmso): from 0.0 to 0.3 for the first,\nfrom 0.3 to 0.8 for the second, and from 0.9 to 1.0 for the third sub-region.\nThe thickness of the intermembrane solvent at T =20C decreases from 14.4 +/-\n1.8 A at X_dmso =0.0 to 7.8 +/- 1.8 A at X_dmso =0.1. The data were used to\ndetermine the number of free water molecules in the intermembrane space in the\npresence of DMSO. The results for 0.0 \u003c X_dmso \u003c 0.3 were explained in the\nframework of DMSO-induced dehydration of the intermembrane space.",
"arxiv_id": "physics/0108019",
"authors": [
"M. A. Kiselev",
"P. Lesieur",
"A. M. Kisselev",
"C. Grabielle-Madelmond",
"M. Ollivon"
],
"categories": [
"physics.bio-ph",
"cond-mat.soft",
"physics.chem-ph",
"physics.med-ph"
],
"journal_ref": "Journal of Alloys and Compounds 286 (1999) 195-202",
"title": "DMSO-Induced Dehydration of DPPC Membranes Studied by X-ray Diffraction, Small-Angle Neutron Scattering, and Calorimetry",
"url": "https://arxiv.org/abs/physics/0108019"
},
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