dorsal/arxiv
View SchemaBow-tie topological features of metabolic networks and the functional significance
| Authors | Zhao Jing, Tao Lin, Yu Hong, Luo Jian-Hua, Z. W. Cao, Li Yixue |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611013 |
| URL | https://arxiv.org/abs/q-bio/0611013 |
| Journal | Chinese Science Bulletin 2007, 52:1036 - 1045 |
Abstract
Exploring the structural topology of genome-based large-scale metabolic network is essential for investigating possible relations between structure and functionality. Visualization would be helpful for obtaining immediate information about structural organization. In this work, metabolic networks of 75 organisms were investigated from a topological point of view. A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks. The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks. This coarse-grained graph also visualizes the vulnerable connections in the network, and thus could have important implication for disease studies and drug target identifications. In addition, analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks.
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"abstract": "Exploring the structural topology of genome-based large-scale metabolic\nnetwork is essential for investigating possible relations between structure and\nfunctionality. Visualization would be helpful for obtaining immediate\ninformation about structural organization. In this work, metabolic networks of\n75 organisms were investigated from a topological point of view. A spread\nbow-tie model was proposed to give a clear visualization of the bow-tie\nstructure for metabolic networks. The revealed topological pattern helps to\ndesign more efficient algorithm specifically for metabolic networks. This\ncoarse-grained graph also visualizes the vulnerable connections in the network,\nand thus could have important implication for disease studies and drug target\nidentifications. In addition, analysis on the reciprocal links and main cores\nin the GSC part of bow-tie also reveals that the bow-tie structure of metabolic\nnetworks has its own intrinsic and significant features which are significantly\ndifferent from those of random networks.",
"arxiv_id": "q-bio/0611013",
"authors": [
"Zhao Jing",
"Tao Lin",
"Yu Hong",
"Luo Jian-Hua",
"Z. W. Cao",
"Li Yixue"
],
"categories": [
"q-bio.MN"
],
"journal_ref": "Chinese Science Bulletin 2007, 52:1036 - 1045",
"title": "Bow-tie topological features of metabolic networks and the functional significance",
"url": "https://arxiv.org/abs/q-bio/0611013"
},
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