dorsal/arxiv
View SchemaTwo-State Migration of DNA in a structured Microchannel
| Authors | Martin Streek, Friederike Schmid, Thanh Tu Duong, Dario Anselmetti, Alexandra Ros |
|---|---|
| Categories | |
| ArXiv ID | physics/0406008 |
| URL | https://arxiv.org/abs/physics/0406008 |
| DOI | 10.1103/PhysRevE.71.011905 |
Abstract
DNA migration in topologically structured microchannels with periodic cavities is investigated experimentally and with Brownian dynamics simulations of a simple bead-spring model. The results are in very good agreement with one another. In particular, the experimentally observed migration order of Lambda- and T2-DNA molecules is reproduced by the simulations. The simulation data indicate that the mobility may depend on the chain length in a nonmonotonic way at high electric fields. This is found to be the signature of a nonequilibrium phase transition between two different migration states, a slow one and a fast one, which can also be observed experimentally under appropriate conditions.
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"abstract": "DNA migration in topologically structured microchannels with periodic\ncavities is investigated experimentally and with Brownian dynamics simulations\nof a simple bead-spring model. The results are in very good agreement with one\nanother. In particular, the experimentally observed migration order of Lambda-\nand T2-DNA molecules is reproduced by the simulations. The simulation data\nindicate that the mobility may depend on the chain length in a nonmonotonic way\nat high electric fields. This is found to be the signature of a nonequilibrium\nphase transition between two different migration states, a slow one and a fast\none, which can also be observed experimentally under appropriate conditions.",
"arxiv_id": "physics/0406008",
"authors": [
"Martin Streek",
"Friederike Schmid",
"Thanh Tu Duong",
"Dario Anselmetti",
"Alexandra Ros"
],
"categories": [
"physics.bio-ph",
"q-bio.BM"
],
"doi": "10.1103/PhysRevE.71.011905",
"title": "Two-State Migration of DNA in a structured Microchannel",
"url": "https://arxiv.org/abs/physics/0406008"
},
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