{
  "annotation_id": "f485d813-b5ab-432f-9b21-2c2e5fbd968e",
  "date_created": "2026-03-02T18:00:39.866000Z",
  "date_modified": "2026-03-02T18:00:39.866000Z",
  "file_hash": "08d37e354aedb3960d1c15f24d8e7ba15261533181def8e591830f69d7af8d80",
  "private": false,
  "record": {
    "abstract": "Active (catalysed) and passive (intrinsic) nucleosome repositioning is known\nto be a crucial event during the transcriptional activation of certain\neucaryotic genes. Here we consider theoretically the intrinsic mechanism and\nstudy in detail the energetics and dynamics of DNA-loop-mediated nucleosome\nrepositioning, as previously proposed by Schiessel et al. (H. Schiessel, J.\nWidom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\\it Phys. Rev. Lett.}\n86:4414-4417). The surprising outcome of the present study is the inherent\nnonlocality of nucleosome motion within this model -- being a direct physical\nconsequence of the loop mechanism. On long enough DNA templates the longer\njumps dominate over the previously predicted local motion, a fact that\ncontrasts simple diffusive mechanisms considered before. The possible\nexperimental outcome resulting from the considered mechanism is predicted,\ndiscussed and compared to existing experimental findings.",
    "arxiv_id": "physics/0206084",
    "authors": [
      "I. M. Kulic",
      "H. Schiessel"
    ],
    "categories": [
      "physics.bio-ph",
      "cond-mat.soft",
      "q-bio"
    ],
    "doi": "10.1016/S0006-3495(03)70044-7",
    "title": "Nucleosome repositioning via loop formation",
    "url": "https://arxiv.org/abs/physics/0206084"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "7ef1fd12-6572-46b9-86a4-7309bca8fbfd",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}