dorsal/arxiv
View SchemaNucleosome repositioning via loop formation
| Authors | I. M. Kulic, H. Schiessel |
|---|---|
| Categories | |
| ArXiv ID | physics/0206084 |
| URL | https://arxiv.org/abs/physics/0206084 |
| DOI | 10.1016/S0006-3495(03)70044-7 |
Abstract
Active (catalysed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eucaryotic genes. Here we consider theoretically the intrinsic mechanism and study in detail the energetics and dynamics of DNA-loop-mediated nucleosome repositioning, as previously proposed by Schiessel et al. (H. Schiessel, J. Widom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\it Phys. Rev. Lett.} 86:4414-4417). The surprising outcome of the present study is the inherent nonlocality of nucleosome motion within this model -- being a direct physical consequence of the loop mechanism. On long enough DNA templates the longer jumps dominate over the previously predicted local motion, a fact that contrasts simple diffusive mechanisms considered before. The possible experimental outcome resulting from the considered mechanism is predicted, discussed and compared to existing experimental findings.
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"abstract": "Active (catalysed) and passive (intrinsic) nucleosome repositioning is known\nto be a crucial event during the transcriptional activation of certain\neucaryotic genes. Here we consider theoretically the intrinsic mechanism and\nstudy in detail the energetics and dynamics of DNA-loop-mediated nucleosome\nrepositioning, as previously proposed by Schiessel et al. (H. Schiessel, J.\nWidom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\\it Phys. Rev. Lett.}\n86:4414-4417). The surprising outcome of the present study is the inherent\nnonlocality of nucleosome motion within this model -- being a direct physical\nconsequence of the loop mechanism. On long enough DNA templates the longer\njumps dominate over the previously predicted local motion, a fact that\ncontrasts simple diffusive mechanisms considered before. The possible\nexperimental outcome resulting from the considered mechanism is predicted,\ndiscussed and compared to existing experimental findings.",
"arxiv_id": "physics/0206084",
"authors": [
"I. M. Kulic",
"H. Schiessel"
],
"categories": [
"physics.bio-ph",
"cond-mat.soft",
"q-bio"
],
"doi": "10.1016/S0006-3495(03)70044-7",
"title": "Nucleosome repositioning via loop formation",
"url": "https://arxiv.org/abs/physics/0206084"
},
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