{
  "annotation_id": "f4859afd-ac01-4e46-86bc-22671a75fb0c",
  "date_created": "2026-03-02T18:00:36.339000Z",
  "date_modified": "2026-03-02T18:00:36.339000Z",
  "file_hash": "a492fd2449349197f22e6546c5a4ba05cffb80e41a7d122cbd607847382b1eb5",
  "private": false,
  "record": {
    "abstract": "The opening rate of voltage-gated potassium ion channels exhibits a\ncharacteristic, knee-like turnover where the common exponential\nvoltage-dependence changes suddenly into a linear one. An explanation of this\npuzzling crossover is put forward in terms of a stochastic first passage time\nanalysis. The theory predicts that the exponential voltage-dependence\ncorrelates with the exponential distribution of closed residence times. This\nfeature occurs at large negative voltages when the channel is predominantly\nclosed. In contrast, the linear part of voltage-dependence emerges together\nwith a non-exponential distribution of closed dwelling times with increasing\nvoltage, yielding a large opening rate. Depending on the parameter set, the\nclosed-time distribution displays a power law behavior which extends over\nseveral decades.",
    "arxiv_id": "physics/0111187",
    "authors": [
      "Igor Goychuk",
      "Peter H\u00e4nggi"
    ],
    "categories": [
      "physics.bio-ph",
      "cond-mat.stat-mech",
      "physics.chem-ph"
    ],
    "doi": "10.1073/pnas.052015699",
    "journal_ref": "Proc. Natl. Acad. Sci. USA 99, 3552-3556 (2002)",
    "title": "Ion channel gating: a first passage time analysis of the Kramers type",
    "url": "https://arxiv.org/abs/physics/0111187"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "9842d6a1-d17a-45f8-9012-94f2b58e4442",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}