dorsal/arxiv
View SchemaIon channel gating: a first passage time analysis of the Kramers type
| Authors | Igor Goychuk, Peter Hänggi |
|---|---|
| Categories | |
| ArXiv ID | physics/0111187 |
| URL | https://arxiv.org/abs/physics/0111187 |
| DOI | 10.1073/pnas.052015699 |
| Journal | Proc. Natl. Acad. Sci. USA 99, 3552-3556 (2002) |
Abstract
The opening rate of voltage-gated potassium ion channels exhibits a characteristic, knee-like turnover where the common exponential voltage-dependence changes suddenly into a linear one. An explanation of this puzzling crossover is put forward in terms of a stochastic first passage time analysis. The theory predicts that the exponential voltage-dependence correlates with the exponential distribution of closed residence times. This feature occurs at large negative voltages when the channel is predominantly closed. In contrast, the linear part of voltage-dependence emerges together with a non-exponential distribution of closed dwelling times with increasing voltage, yielding a large opening rate. Depending on the parameter set, the closed-time distribution displays a power law behavior which extends over several decades.
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"abstract": "The opening rate of voltage-gated potassium ion channels exhibits a\ncharacteristic, knee-like turnover where the common exponential\nvoltage-dependence changes suddenly into a linear one. An explanation of this\npuzzling crossover is put forward in terms of a stochastic first passage time\nanalysis. The theory predicts that the exponential voltage-dependence\ncorrelates with the exponential distribution of closed residence times. This\nfeature occurs at large negative voltages when the channel is predominantly\nclosed. In contrast, the linear part of voltage-dependence emerges together\nwith a non-exponential distribution of closed dwelling times with increasing\nvoltage, yielding a large opening rate. Depending on the parameter set, the\nclosed-time distribution displays a power law behavior which extends over\nseveral decades.",
"arxiv_id": "physics/0111187",
"authors": [
"Igor Goychuk",
"Peter H\u00e4nggi"
],
"categories": [
"physics.bio-ph",
"cond-mat.stat-mech",
"physics.chem-ph"
],
"doi": "10.1073/pnas.052015699",
"journal_ref": "Proc. Natl. Acad. Sci. USA 99, 3552-3556 (2002)",
"title": "Ion channel gating: a first passage time analysis of the Kramers type",
"url": "https://arxiv.org/abs/physics/0111187"
},
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