{
  "annotation_id": "f42d8deb-74df-4c94-9cd9-1bcee8616c36",
  "date_created": "2026-03-02T18:01:32.237000Z",
  "date_modified": "2026-03-02T18:01:32.237000Z",
  "file_hash": "513b23b489ef78956c1fcb062385c0e07392306a57bc7ef4f3a90fd982c25bf1",
  "private": false,
  "record": {
    "abstract": "We investigate the translocation of a stiff polymer consisting of M monomers\nthrough a nanopore in a membrane, in the presence of binding particles\n(chaperones) that bind onto the polymer, and partially prevent backsliding of\nthe polymer through the pore. The process is characterized by the rates: k for\nthe polymer to make a diffusive jump through the pore, q for unbinding of a\nchaperone, and the rate q kappa for binding (with a binding strength kappa);\nexcept for the case of no binding kappa=0 the presence of the chaperones give\nrise to an effective force that drives the translocation process. Based on a\n(2+1) variate master equation, we study in detail the coupled dynamics of\ndiffusive translocation and (partial) rectification by the binding proteins. In\nparticular, we calculate the mean translocation time as a function of the\nvarious physical parameters.",
    "arxiv_id": "q-bio/0508029",
    "authors": [
      "T. Ambjoernsson",
      "M. A. Lomholt",
      "R. Metzler"
    ],
    "categories": [
      "q-bio.BM",
      "cond-mat.soft"
    ],
    "doi": "10.1088/0953-8984/17/47/021",
    "title": "Directed motion emerging from two coupled random processes:   Translocation of a chain through a membrane nanopore driven by binding   proteins",
    "url": "https://arxiv.org/abs/q-bio/0508029"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "d895487e-66c2-43d1-a190-92b4f82d80f0",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}