dorsal/arxiv
View SchemaRNA-based Phylogenetic Methods: Application to Mammalian Mitochondrial RNA Sequences
| Authors | Cendrine Hudelot, Vivek Gowri-Shankar, Howsun Jow, Magnus Rattray, Paul G. Higgs |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0404031 |
| URL | https://arxiv.org/abs/q-bio/0404031 |
| Journal | Mol. Phyl. Evol. 28, 241-252. (2003) |
Abstract
The PHASE software package allows phylogenetic tree construction with a number of evolutionary models designed specifically for use with RNA sequences that have conserved secondary structure. Evolution in the paired regions of RNAs occurs via compensatory substitutions, hence changes on either side of a pair are correlated. Accounting for this correlation is important for phylogenetic inference because it affects the likelihood calculation. In the present study we use the complete set of tRNA and rRNA sequences from 69 complete mammalian mitochondrial genomes. The likelihood calculation uses two evolutionary models simultaneously for different parts of the sequence: a paired-site model for the paired sites and a single-site model for the unpaired sites. We use Bayesian phylogenetic methods and a Markov chain Monte Carlo algorithm is used to obtain the most probable trees and posterior probabilities of clades. The results are well resolved for almost all the important branches on the mammalian tree. They support the arrangement of mammalian orders within the four supra-ordinal clades that have been identified by studies of much larger data sets mainly comprising nuclear genes. Groups such as the hedgehogs and the murid rodents, which have been problematic in previous studies with mitochondrial proteins, appear in their expected position with the other members of their order. Our choice of genes and evolutionary model appears to be more reliable and less subject to biases caused by variation in base composition than previous studies with mitochondrial genomes.
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"abstract": "The PHASE software package allows phylogenetic tree construction with a\nnumber of evolutionary models designed specifically for use with RNA sequences\nthat have conserved secondary structure. Evolution in the paired regions of\nRNAs occurs via compensatory substitutions, hence changes on either side of a\npair are correlated. Accounting for this correlation is important for\nphylogenetic inference because it affects the likelihood calculation. In the\npresent study we use the complete set of tRNA and rRNA sequences from 69\ncomplete mammalian mitochondrial genomes. The likelihood calculation uses two\nevolutionary models simultaneously for different parts of the sequence: a\npaired-site model for the paired sites and a single-site model for the unpaired\nsites. We use Bayesian phylogenetic methods and a Markov chain Monte Carlo\nalgorithm is used to obtain the most probable trees and posterior probabilities\nof clades. The results are well resolved for almost all the important branches\non the mammalian tree. They support the arrangement of mammalian orders within\nthe four supra-ordinal clades that have been identified by studies of much\nlarger data sets mainly comprising nuclear genes. Groups such as the hedgehogs\nand the murid rodents, which have been problematic in previous studies with\nmitochondrial proteins, appear in their expected position with the other\nmembers of their order. Our choice of genes and evolutionary model appears to\nbe more reliable and less subject to biases caused by variation in base\ncomposition than previous studies with mitochondrial genomes.",
"arxiv_id": "q-bio/0404031",
"authors": [
"Cendrine Hudelot",
"Vivek Gowri-Shankar",
"Howsun Jow",
"Magnus Rattray",
"Paul G. Higgs"
],
"categories": [
"q-bio.PE"
],
"journal_ref": "Mol. Phyl. Evol. 28, 241-252. (2003)",
"title": "RNA-based Phylogenetic Methods: Application to Mammalian Mitochondrial RNA Sequences",
"url": "https://arxiv.org/abs/q-bio/0404031"
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