dorsal/arxiv
View SchemaForce steps during viral DNA packaging ?
| Authors | Prashant K. Purohit, Jane' Kondev, Rob Phillips |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0309010 |
| URL | https://arxiv.org/abs/q-bio/0309010 |
| DOI | 10.1016/j.jmps.2003.09.016 |
Abstract
Biophysicists and structural biologists increasingly acknowledge the role played by the mechanical properties of macromolecules as a critical element in many biological processes. This change has been brought about, in part, by the advent of single molecule biophysics techniques that have made it possible to exert piconewton forces on key macromolecules and observe their deformations at nanometer length scales, as well as to observe the mechanical action of macromolecules such as molecular motors. This has opened up immense possibilities for a new generation of mechanical investigations that will respond to such measurements in an attempt to develop a coherent theory for the mechanical behavior of macromolecules under conditions where thermal and chemical effects are on an equal footing with deterministic forces. This paper presents an application of the principles of mechanics to the problem of DNA packaging, one of the key events in the life cycle of bacterial viruses with special reference to the nature of the internal forces that are built up during the DNA packaging process.
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"abstract": "Biophysicists and structural biologists increasingly acknowledge the role\nplayed by the mechanical properties of macromolecules as a critical element in\nmany biological processes. This change has been brought about, in part, by the\nadvent of single molecule biophysics techniques that have made it possible to\nexert piconewton forces on key macromolecules and observe their deformations at\nnanometer length scales, as well as to observe the mechanical action of\nmacromolecules such as molecular motors. This has opened up immense\npossibilities for a new generation of mechanical investigations that will\nrespond to such measurements in an attempt to develop a coherent theory for the\nmechanical behavior of macromolecules under conditions where thermal and\nchemical effects are on an equal footing with deterministic forces. This paper\npresents an application of the principles of mechanics to the problem of DNA\npackaging, one of the key events in the life cycle of bacterial viruses with\nspecial reference to the nature of the internal forces that are built up during\nthe DNA packaging process.",
"arxiv_id": "q-bio/0309010",
"authors": [
"Prashant K. Purohit",
"Jane\u0027 Kondev",
"Rob Phillips"
],
"categories": [
"q-bio.BM",
"q-bio.SC"
],
"doi": "10.1016/j.jmps.2003.09.016",
"title": "Force steps during viral DNA packaging ?",
"url": "https://arxiv.org/abs/q-bio/0309010"
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