dorsal/arxiv
View SchemaElastic Correlations in Nucleosomal DNA Structure
| Authors | Farshid Mohammad-Rafiee, Ramin Golestanian |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0701014 |
| URL | https://arxiv.org/abs/q-bio/0701014 |
| DOI | 10.1103/PhysRevLett.94.238102 |
| Journal | Phys. Rev. Lett. 94, 238102 (2005) |
Abstract
The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T.J. Richmond and C.A. Davey, Nature {\bf 423}, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G=25 nm for the value of the twist-bend coupling constant.
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"abstract": "The structure of DNA in the nucleosome core particle is studied using an\nelastic model that incorporates anisotropy in the bending energetics and\ntwist-bend coupling. Using the experimentally determined structure of\nnucleosomal DNA [T.J. Richmond and C.A. Davey, Nature {\\bf 423}, 145 (2003)],\nit is shown that elastic correlations exist between twist, roll, tilt, and\nstretching of DNA, as well as the distance between phosphate groups. The\ntwist-bend coupling term is shown to be able to capture these correlations to a\nlarge extent, and a fit to the experimental data yields a new estimate of G=25\nnm for the value of the twist-bend coupling constant.",
"arxiv_id": "q-bio/0701014",
"authors": [
"Farshid Mohammad-Rafiee",
"Ramin Golestanian"
],
"categories": [
"q-bio.BM",
"cond-mat.soft"
],
"doi": "10.1103/PhysRevLett.94.238102",
"journal_ref": "Phys. Rev. Lett. 94, 238102 (2005)",
"title": "Elastic Correlations in Nucleosomal DNA Structure",
"url": "https://arxiv.org/abs/q-bio/0701014"
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