{
  "annotation_id": "f0c146ee-420f-475d-b7f8-f46093736d60",
  "date_created": "2026-03-02T18:01:31.859000Z",
  "date_modified": "2026-03-02T18:01:31.859000Z",
  "file_hash": "4f65ec7b900327cd11fb0aa1361de28134ec37b20d27cc84f641d04ab94d1dfc",
  "private": false,
  "record": {
    "abstract": "By observing reconstituted chromatin by fluorescence microscopy (FM) and\natomic force microscopy (AFM), we found that the density of nucleosomes\nexhibits a bimodal profile, i.e., there is a large transition between the dense\nand dispersed states in reconstituted chromatin. Based on an analysis of the\nspatial distribution of nucleosome cores, we deduced an effective thermodynamic\npotential as a function of the nucleosome-nucleosome distance. This enabled us\nto interpret the folding transition of chromatin in terms of a first-order\nphase transition. This mechanism for the condensation of chromatin is discussed\nin terms of its biological significance.",
    "arxiv_id": "q-bio/0407011",
    "authors": [
      "Tonau Nakai",
      "Kohji Hizume",
      "Shige. H. Yoshimura",
      "Kunio Takeyasu",
      "Kenichi Yoshikawa"
    ],
    "categories": [
      "q-bio.SC"
    ],
    "doi": "10.1209/epl/i2004-10444-6",
    "journal_ref": "Europhysics Letters, Vol. 69, Iss. 6, pp. 1024-1030 (2005)",
    "title": "Phase Transition in Reconstituted Chromatin",
    "url": "https://arxiv.org/abs/q-bio/0407011"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "d5a4ce39-db3c-4953-a75f-837db805fb17",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}