dorsal/arxiv
View SchemaAsymptotic Evolution of Protein-Protein Interaction Networks for General Duplication-Divergence Models
| Authors | Kirill Evlampiev, Herve Isambert |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611070 |
| URL | https://arxiv.org/abs/q-bio/0611070 |
Abstract
Genomic duplication-divergence events, which are the primary source of new protein functions, occur stochastically at a wide range of genomic scales, from single gene to whole genome duplications. Clearly, this fundamental evolutionary process must have largely conditioned the emerging structure of protein-protein interaction (PPI) networks, that control many cellular activities. We propose and asymptotically solve a general duplication-divergence model of PPI network evolution based on the statistical selection of duplication-derived interactions. We also introduce a conservation index, that formally defines the statistical evolutionary conservation of PPI networks. Distinct conditions on microscopic parameters are then shown to control global conservation and topology of emerging PPI networks. In particular, conserved, non-dense networks, which are the only ones of potential biological relevance, are also shown to be necessary scale-free.
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"abstract": "Genomic duplication-divergence events, which are the primary source of new\nprotein functions, occur stochastically at a wide range of genomic scales, from\nsingle gene to whole genome duplications. Clearly, this fundamental\nevolutionary process must have largely conditioned the emerging structure of\nprotein-protein interaction (PPI) networks, that control many cellular\nactivities. We propose and asymptotically solve a general\nduplication-divergence model of PPI network evolution based on the statistical\nselection of duplication-derived interactions. We also introduce a conservation\nindex, that formally defines the statistical evolutionary conservation of PPI\nnetworks. Distinct conditions on microscopic parameters are then shown to\ncontrol global conservation and topology of emerging PPI networks. In\nparticular, conserved, non-dense networks, which are the only ones of potential\nbiological relevance, are also shown to be necessary scale-free.",
"arxiv_id": "q-bio/0611070",
"authors": [
"Kirill Evlampiev",
"Herve Isambert"
],
"categories": [
"q-bio.MN",
"q-bio.PE"
],
"title": "Asymptotic Evolution of Protein-Protein Interaction Networks for General Duplication-Divergence Models",
"url": "https://arxiv.org/abs/q-bio/0611070"
},
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