dorsal/arxiv
View SchemaMaster equation approach to the assembly of viral capsids
| Authors | T. Keef, C. Micheletti, R. Twarock |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0508030 |
| URL | https://arxiv.org/abs/q-bio/0508030 |
Abstract
The distribution of inequivalent geometries occurring during self-assembly of the major capsid protein in thermodynamic equilibrium is determined based on a master equation approach. These results are implemented to characterize the assembly of SV40 virus and to obtain information on the putative pathways controlling the progressive build-up of the SV40 capsid. The experimental testability of the predictions is assessed and an analysis of the geometries of the assembly intermediates on the dominant pathways is used to identify targets for antiviral drug design.
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"date_created": "2026-03-02T18:01:32.355000Z",
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"abstract": "The distribution of inequivalent geometries occurring during self-assembly of\nthe major capsid protein in thermodynamic equilibrium is determined based on a\nmaster equation approach. These results are implemented to characterize the\nassembly of SV40 virus and to obtain information on the putative pathways\ncontrolling the progressive build-up of the SV40 capsid. The experimental\ntestability of the predictions is assessed and an analysis of the geometries of\nthe assembly intermediates on the dominant pathways is used to identify targets\nfor antiviral drug design.",
"arxiv_id": "q-bio/0508030",
"authors": [
"T. Keef",
"C. Micheletti",
"R. Twarock"
],
"categories": [
"q-bio.BM"
],
"title": "Master equation approach to the assembly of viral capsids",
"url": "https://arxiv.org/abs/q-bio/0508030"
},
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