dorsal/arxiv
View SchemaMultiple, weak hits confuse complex systems: A transcriptional regulatory network as an example
| Authors | Vilmos Agoston, Peter Csermely, Sandor Pongor |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0410026 |
| URL | https://arxiv.org/abs/q-bio/0410026 |
| DOI | 10.1103/PhysRevE.71.051909 |
| Journal | Phys. Rev. E 71, 051909 (2005) |
Abstract
Robust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening of the Escherichia coli and Saccharomyces cerevisiae transcriptional regulatory networks at a small number (3-5) selected nodes can have a greater impact than the complete elimination of a single selected node. In both cases, the targeted nodes have the greatest possible impact; still the results suggest that in some cases broad specificity compounds or multitarget drug therapies may be more effective than individual high-affinity, high-specificity ones. Multiple but partial attacks mimic well a number of in vivo scenarios and may be useful in the efficient modification of other complex systems.
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"abstract": "Robust systems, like the molecular networks of living cells are often\nresistant to single hits such as those caused by high-specificity drugs. Here\nwe show that partial weakening of the Escherichia coli and Saccharomyces\ncerevisiae transcriptional regulatory networks at a small number (3-5) selected\nnodes can have a greater impact than the complete elimination of a single\nselected node. In both cases, the targeted nodes have the greatest possible\nimpact; still the results suggest that in some cases broad specificity\ncompounds or multitarget drug therapies may be more effective than individual\nhigh-affinity, high-specificity ones. Multiple but partial attacks mimic well a\nnumber of in vivo scenarios and may be useful in the efficient modification of\nother complex systems.",
"arxiv_id": "q-bio/0410026",
"authors": [
"Vilmos Agoston",
"Peter Csermely",
"Sandor Pongor"
],
"categories": [
"q-bio.MN",
"q-bio.GN"
],
"doi": "10.1103/PhysRevE.71.051909",
"journal_ref": "Phys. Rev. E 71, 051909 (2005)",
"title": "Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example",
"url": "https://arxiv.org/abs/q-bio/0410026"
},
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