dorsal/arxiv
View SchemaTopological features of proteins from amino acid residue networks
| Authors | Nelson Augusto Alves, Alexandre Souto Martinez |
|---|---|
| Categories | |
| ArXiv ID | physics/0601128 |
| URL | https://arxiv.org/abs/physics/0601128 |
| DOI | 10.1016/j.physa.2006.09.014 |
| Journal | Physica A 375 336--344 (2007) |
Abstract
Topological properties of native folds are obtained from statistical analysis of 160 low homology proteins covering the four structural classes. This is done analysing one, two and three-vertex joint distribution of quantities related to the corresponding network of amino acid residues. Emphasis on the amino acid residue hydrophobicity leads to the definition of their center of mass as vertices in this contact network model with interactions represented by edges. The network analysis helps us to interpret experimental results such as hydrophobic scales and fraction of buried accessible surface area in terms of the network connectivity. To explore the vertex type dependent correlations, we build a network of hydrophobic and polar vertices. This procedure presents the wiring diagram of the topological structure of globular proteins leading to the following attachment probabilities between hydrophobic-hydrophobic 0.424(5), hydrophobic-polar 0.419(2) and polar-polar 0.157(3) residues.
{
"annotation_id": "e92a957e-b4c7-4ab0-9233-9b84b3ae8056",
"date_created": "2026-03-02T18:01:03.865000Z",
"date_modified": "2026-03-02T18:01:03.865000Z",
"file_hash": "c779a841db70a3918a34070f7ac372e84bd67070a14486b7c1b1f702d817fafb",
"private": false,
"record": {
"abstract": "Topological properties of native folds are obtained from statistical analysis\nof 160 low homology proteins covering the four structural classes. This is done\nanalysing one, two and three-vertex joint distribution of quantities related to\nthe corresponding network of amino acid residues. Emphasis on the amino acid\nresidue hydrophobicity leads to the definition of their center of mass as\nvertices in this contact network model with interactions represented by edges.\nThe network analysis helps us to interpret experimental results such as\nhydrophobic scales and fraction of buried accessible surface area in terms of\nthe network connectivity. To explore the vertex type dependent correlations, we\nbuild a network of hydrophobic and polar vertices. This procedure presents the\nwiring diagram of the topological structure of globular proteins leading to the\nfollowing attachment probabilities between hydrophobic-hydrophobic 0.424(5),\nhydrophobic-polar 0.419(2) and polar-polar 0.157(3) residues.",
"arxiv_id": "physics/0601128",
"authors": [
"Nelson Augusto Alves",
"Alexandre Souto Martinez"
],
"categories": [
"physics.bio-ph",
"q-bio.BM"
],
"doi": "10.1016/j.physa.2006.09.014",
"journal_ref": "Physica A 375 336--344 (2007)",
"title": "Topological features of proteins from amino acid residue networks",
"url": "https://arxiv.org/abs/physics/0601128"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "c9a7d6a6-d230-47b2-b62b-fbe160d548a1",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}