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1
State Street ® SPDR ®
S&P ® Biotech ETF
XBI
Fact Sheet
Equity
As of 09/30/2026
Key Features
• The State Street ® SPDR ® S&P ® Biotech ETF seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of the S&P ® Biotechnology Select Industry TM Index (the "Index") • Seeks to provide exposure to the Biotechnology segment of the S&P TMI, which comprises the following sub-industries: Biotechnology • Seeks to track a modified equal weighted index which provides the potential for unconcentrated industry exposure across large, mid and small cap stocks • Allows investors to take strategic or tactical positions at a more targeted level than traditional sector based investing • Ordinary brokerage commissions may apply
About This Benchmark
The S&P Biotechnology Select Industry ® represents the biotechnology segment of the S&P Total Market Index ("S&P TMI"). The S&P TMI is designed to track the broad U.S. equity market. The biotechnology segment of the S&P TMI comprises the Biotechnology sub-industry. The Index is modified equal weighted.
Fund Information Inception Date 01/31/2006 CUSIP 78464A870
Total Return (As of 09/30/2026) NAV (%)
Market Value (%)
Index (%) Cumulative QTD -0.32 -0.32 -0.28 YTD 29.42 29.43 29.67 Annualised 1 Year 58.05 58.10 58.35 3 Year 29.50 29.52 29.66 5 Year 4.77 4.77 4.95 10 Year 9.21 9.20 9.32
Gross Expense Ratio (%) 0.35 Net Expense Ratio (%) 0.35 30 Day SEC Yield (%) -0.14 Performance data quoted represents past performance and is no guarantee of future results. Current performance may be lower or higher than the performance data quoted. Investment return and principal value will fluctuate so that the investor's shares, when redeemed, may be worth more or less than the original cost. All results assume the reinvestment of dividends and capital gains. Performance is shown net of any fees. Periods of less than one year are not annualized. Visit statestreet.com/im for most recent month-end performance. Performance of an index is not illustrative of any particular investment. It is not possible to invest directly in an index. Index returns are unmanaged and do not reflect the deduction of any fees or expenses. Index returns reflect all items of income, gain and loss and the reinvestment of dividends and other income as applicable.
Characteristics Est. 3-5 Year EPS Growth 1.19% Index Dividend Yield 0.12% Price/Earnings Ratio FY1 21.07 Number of Holdings 165 Price/Book 4.76 Average Market Cap (M) US$25,633.12
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Top 10 Holdings Weight (%) TWIST BIOSCIENCE CORP 2.21 MODERNA INC 2.04 NATERA INC 1.80 IOVANCE BIOTHERAPEUTICS INC 1.62 AMGEN INC 1.55 BIOGEN INC 1.54 UNITED THERAPEUTICS CORP 1.54 ABBVIE INC 1.50 HALOZYME THERAPEUTICS INC 1.48 SPYRE THERAPEUTICS INC 1.47 Totals may not equal 100 due to rounding. Source: State Street Investment Management, 30th September 2026. Characteristics/ Holdings/ Weights are subject to change, and should not be relied upon as current thereafter.
statestreet.com/im
Information Classification: General State Street Global Advisors (SSGA) is now State Street Investment Management. Please go to statestreet. com/investment-management for more information.
State Street Investment Management One Congress Street, Boston MA 02114 T: +1 866 787 2257
Glossary NAV The market value of a mutual fund's or ETFs total assets, minus liabilities, divided by the number of shares outstanding. Market Value Determined by the midpoint between the bid/offer prices as of the closing time of the New York Stock Exchange (typically 4:00PM EST) on business days. Gross Expense Ratio The fund's total annual operating expense ratio. It is gross of any fee waivers or expense reimbursements. It can be found in the fund's most recent prospectus. 30 Day SEC Yield (Also known as Standardized Yield) An annualized yield that is calculated by dividing the net investment income earned by the fund over the most recent 30-day period by the current maximum offering price. Est. 3-5 Year EPS Growth Based on the underlying holdings of the fund. The actual earnings estimates for the underlying holdings are provided by FactSet, First Call, I/B/E/S Consensus, and Reuters and are used to calculate a mean 3-5 year EPS growth rate estimate. Index Dividend Yield The weighted average of the underlyings' indicated annual dividend divided by price, expressed as a percentage. Price/Earnings Ratio FY1 The weighted harmonic average of current share price divided by the forecasted one year earnings
per share for each security in the fund. Negative and positive outliers are included in the calculation. Price/Book Ratio The weighted harmonic average of closing market price divided by the most recent reported book value for each security in the fund's portfolio as calculated for the last twelve months.
Important Risk Information Weights are as of the date indicated, are subject to change, and should not be relied upon as current thereafter. Investing involves risk including the risk of loss of principal. The information provided does not constitute investment advice and it should not be relied on as such. It should not be considered a solicitation to buy or an offer to sell a security. It does not take into account any investor's particular investment objectives, strategies, tax status or investment horizon. You should consult your tax and financial advisor. The whole or any part of this work may not be reproduced, copied or transmitted or any of its contents disclosed to third parties without SSGA's express written consent. This communication is not intended to be an investment recommendation or investment advice and should not be relied upon as such. Market Risk: The Fund's investments are subject to changes in general economic conditions, general market fluctuations, and the risks inherent in investment in securities markets. Investment markets can be volatile, and prices of investments can change substantially due to various factors, including, but not limited to, economic growth or recession, changes in interest rates, inflation, changes in the actual or perceived creditworthiness of issuers, and general market liquidity. The Fund is subject to the risk that geopolitical events will disrupt securities markets and adversely affect global economies and markets. Local, regional, or global events such as war, military conflicts,
acts of terrorism, trade policy changes or disputes, the threat or actual imposition of tariffs, natural disasters, the spread of infectious illness or other public health issues, or other events could have a significant impact on the Fund and its investments. Equity securities may fluctuate in value and can decline significantly in response to the activities of individual companies and general market and economic conditions. Funds investing in a single sector may be subject to more volatility than funds investing in a diverse group of sectors. Because of their narrow focus, sector funds tend to be more volatile than broadly diversified funds and generally result in greater price fluctuations than the overall market. The Fund is classified as "diversified" under the Investment Company Act of 1940, as amended (the "1940 Act"); however, the Fund may become "non-diversified," as defined under the 1940 Act, solely as a result of tracking the Index (e.g., changes in weightings of one or more component securities). When the Fund is non-diversified, it may invest a relatively high percentage of its assets in a limited number of issuers. Passively managed funds invest by sampling the index, holding a range of securities that, in the aggregate, approximates the full Index in terms of key risk factors and other characteristics. This may cause the fund to experience tracking errors relative to performance of the index. While the shares of ETFs are tradable on secondary markets, they may not readily trade in all market conditions and may trade at significant discounts in periods of market stress . ETFs trade like stocks, are subject to investment risk, fluctuate in market value and may trade at prices above or below the ETFs net asset value. Brokerage commissions and ETF expenses will reduce returns. Intellectual Property Information: The S&P 500 ® Index is a product of S&P Dow Jones Indices LLC or its affiliates ("S&P DJI") and have been licensed for use by State Street
Global Advisors. S&P ® , SPDR ® , S&P 500 ® ,US 500 and the 500 are trademarks of Standard & Poor's Financial Services LLC ("S&P"); Dow Jones ® is a registered trademark of Dow Jones Trademark Holdings LLC ("Dow Jones") and has been licensed for use by S&P Dow Jones Indices; and these trademarks have been licensed for use by S&P DJI and sublicensed for certain purposes by State Street Global Advisors. The fund is not sponsored, endorsed, sold or promoted by S&P DJI, Dow Jones, S&P, their respective affiliates, and none of such parties make any representation regarding the advisability of investing in such product(s) nor do they have any liability for any errors, omissions, or interruptions of these indices. The S&P Select Industry series is designed to measure the performance of narrow GICS (Global Industry Classification Standard) sub-industries. The S&P Biotech Select Industry Index is an equal-weighted index that draws constituents from the Biotechnology segment of the S&P TMI. Liquidity and market capitalization screens are applied to the index to ensure investability. Distributor State Street Global Advisors Funds Distributors, LLC, member FINRA , SIPC , an indirect wholly owned subsidiary of State Street Corporation. References to State Street may include State Street Corporation and its affiliates. Certain State Street affiliates provide services and receive fees from the SPDR ETFs. Before investing in a fund, consider its investment objectives, risks, charges, and expenses. A prospectus (and/or summary prospectus) containing this and other information is available at statestreet.com/im or by calling 1-866-787-2257. Read it carefully.
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For More Information Visit our website at www.statestreet.com/im. Contact our SPDR ETF Sales and Support team at spdrseurope@ssga.com or call your local SPDR ETF representative. United Kingdom: +44 (0)20 3395 6888 | Netherlands: +31 (0)20 718 1016
Marketing Communication: For Professional Client/Qualified Investor Use Only in the Netherlands and United Kingdom. Not for public distribution. This document has been issued by State Street Global Advisors Limited ("SSGA"). Authorised and regulated by the Financial Conduct Authority. Registered No. 2509928. VAT No. 5776591 81. Registered office: 20 Churchill Place, Canary Wharf, London, E14 5HJ. Telephone: 020 3395 6000. Facsimile: 020 3395 6350 Web: www. statestreet.com/im. Netherlands: State Street Global Advisors Netherlands, Apollo Building 7th floor, Herikerbergweg 29, 1101 CN Amsterdam, Netherlands. T: +31 20 7181 000. State Street Global Advisors Netherlands is a branch office of State Street Global Advisors Europe Limited, registered in Ireland with company number 49934, authorised and regulated by the Central Bank of Ireland, and whose registered office is at 78 Sir John Rogerson's Quay, Dublin 2. NOTICE TO PERSONS IN THE EUROPEAN ECONOMIC AREA ("EEA") The fund is permitted to market into the relevant EEA jurisdiction pursuant to either Article 42 of AIFMD (if and as implemented under national laws of such member state); or (ii) can otherwise be lawfully offered or
sold (including on the basis of an unsolicited request from a professional client/qualified investor). The Fund is an alternative investment fund for the purpose of the European Union Alternative Investment Fund Managers Directive (Directive 2011/61/ EU) (the "AIFMD"). It is not a regulated collective investment scheme for purposes of the Financial Services and Markets Act 2000 of the United Kingdom ("FSMA"). The promotion of the fund and the distribution of this material in the UK is restricted by law to Professional Investors Only. The information provided does not constitute tax advice, investors should consult their tax advisors with respect to their particular tax situations and the tax effects of an investment in the Fund. The fund is an alternative investment fund for the purpose of the European Union Alternative Investment Fund Managers Directive (Directive 2011/61/ EU) ("AIFMD"). SSGA Funds Management, Inc. or State Street Global Advisors Trust Company is the alternative investment fund manager ("AIFM") of the fund.
SSGA Funds Management, Inc. serves as the investment advisor to the SPDR ETFs that are registered with the United States Securities and Exchange Commission under the Investment Company Act of 1940. SSGA Funds Management, Inc. is an affiliate of State Street Global Advisors Limited.
Diversification does not ensure a profit or guarantee against loss.
The information provided does not constitute investment advice as such term is defined under the Markets in Financial Instruments Directive (2014/65/EU) and it should not be relied on as such. It should not be considered a solicitation to buy or an offer to sell any investment. It does not take into account any investor's or potential investor’s particular investment objectives, strategies, tax status, risk appetite or investment horizon. If you require investment advice you should consult your tax and financial or other professional advisor.
Key/Investment Risk Disclosures: Capital at risk. Investing involves risk including the risk of loss of principal. Foreign Securities may be subject to greater political, economic, environmental, credit and information risks. Foreign securities may be subject to higher volatility than U.S. securities, due to varying degrees of regulation and limited liquidity.
Before investing, consider the funds' investment objectives, risks, charges and expenses. To obtain a prospectus which contains this and other information, visit www.statestreet.com/im or talk to your financial advisor. Read it carefully before investing.
The whole or any part of this work may not be reproduced, copied or transmitted or any of its contents disclosed to third parties without State Street Investment Management's express written consent.
The information contained in this communication is not a research
recommendation or 'investment research' and is classified as a 'Marketing Communication' in accordance with the Markets in Financial Instruments Directive (2014/65/EU) or applicable Swiss regulation. This means that this marketing communication (a) has not been prepared in accordance with legal requirements designed to promote the independence of investment research (b) is not subject to any prohibition on dealing ahead of the dissemination of investment research. This communication is directed at professional clients (this includes eligible counterparties as defined by the appropriate EU regulator) who are deemed both knowledgeable and experienced in matters relating to investments. The products and services to which this communication relates are only available to such persons and persons of any other description (including retail clients) should not rely on this communication. All information is from SSGA unless otherwise noted and has been obtained from sources believed to be reliable, but its accuracy is not guaranteed. There is no representation or warranty as to the current accuracy, reliability or completeness of, nor liability for, decisions based on such information and it should not be relied on as such.
Tracking Number: 7728691.1.1.EMEA.INST © 2026 State Street Corporation. All Rights Reserved. Expiration Date: 01/31/2027 ETF-XBI 20261007/19:26
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"text": "Weight (%)"
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},
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"text": "TWIST BIOSCIENCE CORP"
},
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},
"id": "541069bb-5959-4736-b62a-f6e7b4c379f2",
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"text": "2.21"
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"id": "5596c088-98a1-43af-8424-f5a2c32eac88",
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"text": "MODERNA INC"
},
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},
"id": "04b20b7f-cfd0-4165-a8f3-47ea949deb3a",
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"text": "NATERA INC"
},
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"x": 453,
"y": 100
},
"id": "dfde5a03-86cf-434b-b7b2-46ab7d9700eb",
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"text": "1.80"
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"id": "f876d0ae-60d8-413a-8987-14a34a3c53d1",
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"text": "IOVANCE BIOTHERAPEUTICS INC"
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},
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"y": 137
},
"id": "29e645f9-e26f-45aa-8962-92c8551a8efb",
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"text": "AMGEN INC"
},
{
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"x": 453,
"y": 137
},
"id": "404ed095-bd81-4423-a5b0-7b63c25d4e7a",
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"text": "1.55"
},
{
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},
"id": "e29ee3ee-33a3-4503-ab01-021fd108dc54",
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"text": "BIOGEN INC"
},
{
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},
"id": "31ac75ed-a6e7-4f5e-be5d-86d9848f3dd0",
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"text": "1.54"
},
{
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},
"id": "63c34381-aebe-44bd-90ba-4092ba023a99",
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"text": "UNITED THERAPEUTICS CORP"
},
{
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"x": 453,
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},
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},
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},
"id": "46681e34-586b-4aa9-bbcb-052eb98aae25",
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"text": "ABBVIE INC"
},
{
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"y": 191
},
"id": "d3fc8305-0132-4e7c-8ec8-a7fc5b298a4a",
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"text": "1.50"
},
{
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"y": 209
},
"id": "727904b0-aa73-477b-ab15-1296cdfbdbb6",
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"text": "HALOZYME THERAPEUTICS INC"
},
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"x": 453,
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},
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"text": "1.48"
},
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},
"id": "551f2f4e-9b41-4a42-9203-b0800239e144",
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"text": "SPYRE THERAPEUTICS INC"
},
{
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"x": 453,
"y": 228
},
"id": "fb820f61-406b-43a3-8c14-8abe893baa8f",
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"text": "1.47"
},
{
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},
"id": "896559f2-8ff4-40e0-85cb-c50f46b9ca72",
"page_number": 2,
"text": "Totals may not equal 100 due to rounding."
},
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},
"id": "c5758c6e-b3de-429f-88b3-3f46b43c8dd9",
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"text": "Source: State Street Investment Management, 30th September 2026."
},
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"text": "Characteristics/ Holdings/ Weights are subject to change, and should not be"
},
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},
"id": "4e62cac6-3587-4c68-8b40-5638b518ea4c",
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"text": "relied upon as current thereafter."
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},
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"text": "Information Classification: General"
},
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},
"id": "5b0d9334-33fe-4efe-b8b6-bc894ef67e4a",
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"text": "State Street Global Advisors (SSGA)"
},
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},
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"text": "is now State Street Investment"
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},
"id": "ef7dd3dd-016b-406f-a7f2-6b791eb1bac3",
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"text": "Management. Please go to statestreet."
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},
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"text": "One Congress Street, Boston MA 02114"
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"text": "T: +1 866 787 2257"
},
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"text": "The market value of a mutual fund\u0027s or"
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"text": "ETFs total assets, minus liabilities, divided by"
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"text": "the number of shares outstanding."
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"text": "between the bid/offer prices as of the closing"
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"text": "time of the New York Stock Exchange (typically"
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"text": "4:00PM EST) on business days."
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"text": "Standardized Yield) An annualized yield that"
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...