dorsal/arxiv
View SchemaTheory of genomic dark matter and biological relativity
| Authors | Mark Ya. Azbel |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611027 |
| URL | https://arxiv.org/abs/q-bio/0611027 |
Abstract
Significant fraction (about 98.5% in humans, 24% in microbe Rickettsia prowazekii) of most animal genomes is non-coding DNA. Although recent studies established functions of its certain portions, it remains genomic dark matter. The paper unravels its unusual nature with time reversal approach. Any genome emerged in evolutionary selection of the fittest survivors. Survivability of modern species is extensively quantified. Accurate analysis establishes that under specified conditions it is dominated by the same law in species from human to single-cell yeast. Since all violators of the law perished in the previous evolution, it presents the exact law of unanticipated universal (rather than species specific natural) evolutionary selection of survivors. The law implies their rapid hereditary, thus genetic, adaptation which is navigated by operating system of non-coding DNA. Such adaptation to drastic environmental changes was a must for survival, thus evolved, in otherwise lethal major mass extinctions. Navigator genome allows for rapid, artificial included, biological changes (e.g., Methuselah lifespan). Universal law establishes biological relativity to age transformation in any species; quantifies applicability of animal models to humans; implies certain universality in biological complexity and reduces it to exact science problem. Evolutionary and experimental data corroborate all above conclusions. Further theoretical study and test-stone experiments are suggested.
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"abstract": "Significant fraction (about 98.5% in humans, 24% in microbe Rickettsia\nprowazekii) of most animal genomes is non-coding DNA. Although recent studies\nestablished functions of its certain portions, it remains genomic dark matter.\nThe paper unravels its unusual nature with time reversal approach. Any genome\nemerged in evolutionary selection of the fittest survivors. Survivability of\nmodern species is extensively quantified. Accurate analysis establishes that\nunder specified conditions it is dominated by the same law in species from\nhuman to single-cell yeast. Since all violators of the law perished in the\nprevious evolution, it presents the exact law of unanticipated universal\n(rather than species specific natural) evolutionary selection of survivors. The\nlaw implies their rapid hereditary, thus genetic, adaptation which is navigated\nby operating system of non-coding DNA. Such adaptation to drastic environmental\nchanges was a must for survival, thus evolved, in otherwise lethal major mass\nextinctions. Navigator genome allows for rapid, artificial included, biological\nchanges (e.g., Methuselah lifespan). Universal law establishes biological\nrelativity to age transformation in any species; quantifies applicability of\nanimal models to humans; implies certain universality in biological complexity\nand reduces it to exact science problem. Evolutionary and experimental data\ncorroborate all above conclusions. Further theoretical study and test-stone\nexperiments are suggested.",
"arxiv_id": "q-bio/0611027",
"authors": [
"Mark Ya. Azbel"
],
"categories": [
"q-bio.GN",
"cond-mat.other",
"nlin.AO",
"physics.bio-ph",
"q-bio.PE"
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"title": "Theory of genomic dark matter and biological relativity",
"url": "https://arxiv.org/abs/q-bio/0611027"
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