{
  "annotation_id": "e64c44d4-0f15-424b-a6fc-3c01e8f01214",
  "date_created": "2026-03-02T18:01:31.549000Z",
  "date_modified": "2026-03-02T18:01:31.549000Z",
  "file_hash": "dcb442d9e2ed8066fb4015ff0bfc8d4a16e3939cbe257e24b908ded4f0cf408d",
  "private": false,
  "record": {
    "abstract": "We address the controversial hot question concerning the validity of the\nloose coupling versus the lever-arm theories in the actomyosin dynamics by\nre-interpreting and extending the phenomenological washboard potential model\nproposed by some of us in a previous paper. In this new model a Brownian motion\nharnessing thermal energy is assumed to co-exist with the deterministic swing\nof the lever-arm, to yield an excellent fit of the set of data obtained by some\nof us on the sliding of Myosin II heads on immobilized actin filaments under\nvarious load conditions. Our theoretical arguments are complemented by accurate\nnumerical simulations, and the robustness of the model is tested via different\nchoices of parameters and potential profiles.",
    "arxiv_id": "q-bio/0504023",
    "authors": [
      "A. Buonocore",
      "L. Caputo",
      "Y. Ishii",
      "E. Pirozzi",
      "T. Yanagida",
      "L. M. Ricciardi"
    ],
    "categories": [
      "q-bio.SC"
    ],
    "title": "On Myosin II dynamics in the presence of external loads",
    "url": "https://arxiv.org/abs/q-bio/0504023"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "6f379b52-0a1e-416b-8ecb-fae2f9b9a087",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}