dorsal/arxiv
View SchemaThe large-scale logico-chemical structure of a transcriptional regulation network
| Authors | M. Cosentino Lagomarsino, P. Jona, B. Bassetti |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0502017 |
| URL | https://arxiv.org/abs/q-bio/0502017 |
Abstract
Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the interplay between a gene repertoire and the regulatory machinery of the cell. At the transcriptional level, the cis-regulatory regions establish sets of interdependencies between transcription factors and genes, including other transcription factors. These ``transcription networks'' are too large to be approached globally with a detailed dynamical model. In this paper, we describe an approach to this problem that focuses solely on the compatibility between gene expression patterns and signal integration functions, discussing calculations carried on the simplest, Boolean, realization of the model, and a first application to experimental data sets.
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"abstract": "Identity, response to external stimuli, and spatial architecture of a living\nsystem are central topics of molecular biology. Presently, they are largely\nseen as a result of the interplay between a gene repertoire and the regulatory\nmachinery of the cell. At the transcriptional level, the cis-regulatory regions\nestablish sets of interdependencies between transcription factors and genes,\nincluding other transcription factors. These ``transcription networks\u0027\u0027 are too\nlarge to be approached globally with a detailed dynamical model. In this paper,\nwe describe an approach to this problem that focuses solely on the\ncompatibility between gene expression patterns and signal integration\nfunctions, discussing calculations carried on the simplest, Boolean,\nrealization of the model, and a first application to experimental data sets.",
"arxiv_id": "q-bio/0502017",
"authors": [
"M. Cosentino Lagomarsino",
"P. Jona",
"B. Bassetti"
],
"categories": [
"q-bio.MN",
"cond-mat.dis-nn"
],
"title": "The large-scale logico-chemical structure of a transcriptional regulation network",
"url": "https://arxiv.org/abs/q-bio/0502017"
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