dorsal/arxiv
View SchemaDesensitization of a balance with Langmuir binding of weights
| Authors | Richard Lanzara |
|---|---|
| Categories | |
| ArXiv ID | physics/0303055 |
| URL | https://arxiv.org/abs/physics/0303055 |
Abstract
A balance is described with Langmuir binding of weights to each side. This simple physical system, when coupled with a previously derived equation for the equivalent displacement of weight that perturbs the equilibrium of a balance, models two-state, receptor systems in pharmacology for receptor activation. Surprisingly, this system also shows desensitization similar to many drug-receptor systems. Although understanding the biophysics behind receptor signaling is an important endeavor by itself, this analogy with a simple balance may bring new insights into other areas of physics as well.
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"abstract": "A balance is described with Langmuir binding of weights to each side. This\nsimple physical system, when coupled with a previously derived equation for the\nequivalent displacement of weight that perturbs the equilibrium of a balance,\nmodels two-state, receptor systems in pharmacology for receptor activation.\nSurprisingly, this system also shows desensitization similar to many\ndrug-receptor systems. Although understanding the biophysics behind receptor\nsignaling is an important endeavor by itself, this analogy with a simple\nbalance may bring new insights into other areas of physics as well.",
"arxiv_id": "physics/0303055",
"authors": [
"Richard Lanzara"
],
"categories": [
"physics.bio-ph",
"q-bio.QM"
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"title": "Desensitization of a balance with Langmuir binding of weights",
"url": "https://arxiv.org/abs/physics/0303055"
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