dorsal/arxiv
View SchemaA mechanism for polar protein localization in bacteria
| Authors | Martin Howard |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0312015 |
| URL | https://arxiv.org/abs/q-bio/0312015 |
| Journal | J. Mol. Biol. 335 655-663 (2004) |
Abstract
We investigate a mechanism for the polar localization of proteins in bacteria. We focus on the MinCD/DivIVA system regulating division site placement in the rod-shaped bacterium Bacillus subtilis. Our model relies on a combination of geometric effects and reaction-diffusion dynamics to direct proteins to both cell poles, where division is then blocked. We discuss similarities and differences with related division models in Escherichia coli and also develop extensions of the model to asymmetric polar protein localization. We propose that our mechanism for polar localization may be employed more widely in bacteria, especially in outgrowing spores, which do not possess any pre-existing polar division apparatus from prior division events.
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"abstract": "We investigate a mechanism for the polar localization of proteins in\nbacteria. We focus on the MinCD/DivIVA system regulating division site\nplacement in the rod-shaped bacterium Bacillus subtilis. Our model relies on a\ncombination of geometric effects and reaction-diffusion dynamics to direct\nproteins to both cell poles, where division is then blocked. We discuss\nsimilarities and differences with related division models in Escherichia coli\nand also develop extensions of the model to asymmetric polar protein\nlocalization. We propose that our mechanism for polar localization may be\nemployed more widely in bacteria, especially in outgrowing spores, which do not\npossess any pre-existing polar division apparatus from prior division events.",
"arxiv_id": "q-bio/0312015",
"authors": [
"Martin Howard"
],
"categories": [
"q-bio.SC",
"cond-mat.soft"
],
"journal_ref": "J. Mol. Biol. 335 655-663 (2004)",
"title": "A mechanism for polar protein localization in bacteria",
"url": "https://arxiv.org/abs/q-bio/0312015"
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