dorsal/arxiv
View SchemaGeometry and symmetry presculpt the free-energy landscape of proteins
| Authors | Trinh Xuan Hoang, Antonio Trovato, Flavio Seno, Jayanth R. Banavar, Amos Maritan |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0405019 |
| URL | https://arxiv.org/abs/q-bio/0405019 |
| DOI | 10.1073/pnas.0402525101 |
| Journal | PNAS 101, 7960-7964 (2004) |
Abstract
We present a simple physical model which demonstrates that the native state folds of proteins can emerge on the basis of considerations of geometry and symmetry. We show that the inherent anisotropy of a chain molecule, the geometrical and energetic constraints placed by the hydrogen bonds and sterics, and hydrophobicity are sufficient to yield a free energy landscape with broad minima even for a homopolymer. These minima correspond to marginally compact structures comprising the menu of folds that proteins choose from to house their native-states in. Our results provide a general framework for understanding the common characteristics of globular proteins.
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"abstract": "We present a simple physical model which demonstrates that the native state\nfolds of proteins can emerge on the basis of considerations of geometry and\nsymmetry. We show that the inherent anisotropy of a chain molecule, the\ngeometrical and energetic constraints placed by the hydrogen bonds and sterics,\nand hydrophobicity are sufficient to yield a free energy landscape with broad\nminima even for a homopolymer. These minima correspond to marginally compact\nstructures comprising the menu of folds that proteins choose from to house\ntheir native-states in. Our results provide a general framework for\nunderstanding the common characteristics of globular proteins.",
"arxiv_id": "q-bio/0405019",
"authors": [
"Trinh Xuan Hoang",
"Antonio Trovato",
"Flavio Seno",
"Jayanth R. Banavar",
"Amos Maritan"
],
"categories": [
"q-bio.BM"
],
"doi": "10.1073/pnas.0402525101",
"journal_ref": "PNAS 101, 7960-7964 (2004)",
"title": "Geometry and symmetry presculpt the free-energy landscape of proteins",
"url": "https://arxiv.org/abs/q-bio/0405019"
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