dorsal/arxiv
View SchemaIntestinal gluconeogenesis and glucose transport according to body fuel availability in rats
| Authors | Caroline Habold, Charlotte Foltzer-Jourdainne, Yvon Le Maho, Jean-Hervé Lignot, Hugues Oudart |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0702009 |
| URL | https://arxiv.org/abs/q-bio/0702009 |
| DOI | 10.1113/jphysiol.2005.085217 |
| Journal | J Physiol 566 (15/07/2005) 575-86 |
Abstract
Intestinal hexose absorption and gluconeogenesis have been studied in relation to refeeding after two different fasting phases: a long period of protein sparing during which energy expenditure is derived from lipid oxidation (phase II), and a later phase characterized by a rise in plasma corticosterone triggering protein catabolism (phase III). Such a switch in body fuel uses, leading to changes in body reserves and gluconeogenic precursors, could modulate intestinal gluconeogenesis and glucose transport. The gene and protein levels, and the cellular localization of the sodium-glucose cotransporter SGLT1, and of GLUT5 and GLUT2, as well as that of the key gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (Glc6Pase) were measured. PEPCK and Glc6Pase activities were also determined. In phase III fasted rats, SGLT1 was up-regulated and intestinal glucose uptake rates were higher than in phase II fasted and fed rats. PEPCK and Glc6Pase mRNA, protein levels and activities also increased in phase III. GLUT5 and GLUT2 were down-regulated throughout the fast, but increased after refeeding, with GLUT2 recruited to the apical membrane. The increase in SGLT1 expression during phase III may allow glucose absorption at low concentrations as soon as food is available. Furthermore, an increased epithelial permeability due to fasting may induce a paracellular movement of glucose. In the absence of intestinal GLUT2 during fasting, Glc6Pase could be involved in glucose release to the bloodstream via membrane trafficking. Finally, refeeding triggered GLUT2 and GLUT5 synthesis and apical recruitment of GLUT2, to absorb larger amounts of hexoses.
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"abstract": "Intestinal hexose absorption and gluconeogenesis have been studied in\nrelation to refeeding after two different fasting phases: a long period of\nprotein sparing during which energy expenditure is derived from lipid oxidation\n(phase II), and a later phase characterized by a rise in plasma corticosterone\ntriggering protein catabolism (phase III). Such a switch in body fuel uses,\nleading to changes in body reserves and gluconeogenic precursors, could\nmodulate intestinal gluconeogenesis and glucose transport. The gene and protein\nlevels, and the cellular localization of the sodium-glucose cotransporter\nSGLT1, and of GLUT5 and GLUT2, as well as that of the key gluconeogenic enzymes\nphosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (Glc6Pase)\nwere measured. PEPCK and Glc6Pase activities were also determined. In phase III\nfasted rats, SGLT1 was up-regulated and intestinal glucose uptake rates were\nhigher than in phase II fasted and fed rats. PEPCK and Glc6Pase mRNA, protein\nlevels and activities also increased in phase III. GLUT5 and GLUT2 were\ndown-regulated throughout the fast, but increased after refeeding, with GLUT2\nrecruited to the apical membrane. The increase in SGLT1 expression during phase\nIII may allow glucose absorption at low concentrations as soon as food is\navailable. Furthermore, an increased epithelial permeability due to fasting may\ninduce a paracellular movement of glucose. In the absence of intestinal GLUT2\nduring fasting, Glc6Pase could be involved in glucose release to the\nbloodstream via membrane trafficking. Finally, refeeding triggered GLUT2 and\nGLUT5 synthesis and apical recruitment of GLUT2, to absorb larger amounts of\nhexoses.",
"arxiv_id": "q-bio/0702009",
"authors": [
"Caroline Habold",
"Charlotte Foltzer-Jourdainne",
"Yvon Le Maho",
"Jean-Herv\u00e9 Lignot",
"Hugues Oudart"
],
"categories": [
"q-bio.PE"
],
"doi": "10.1113/jphysiol.2005.085217",
"journal_ref": "J Physiol 566 (15/07/2005) 575-86",
"title": "Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats",
"url": "https://arxiv.org/abs/q-bio/0702009"
},
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