{
  "annotation_id": "dea1d7c9-f20f-492d-94a8-e9a9aca79709",
  "date_created": "2026-03-02T18:01:32.169000Z",
  "date_modified": "2026-03-02T18:01:32.169000Z",
  "file_hash": "eeb3d71112263c9f4314a9734a09dad97b392fe90ad152d70ef5057625d7cd21",
  "private": false,
  "record": {
    "abstract": "The tethered-particle method is a single-molecule technique that has been\nused to explore the dynamics of a variety of macromolecules of biological\ninterest. We give a theoretical analysis of the particle motions in such\nexperiments. Our analysis reveals that the proximity of the tethered bead to a\nnearby surface (the microscope slide) gives rise to a volume-exclusion effect,\nresulting in an entropic force on the molecule. This force stretches the\nmolecule, changing its statistical properties. In particular, the proximity of\nbead and surface brings about intriguing scaling relations between key\nobservables (statistical moments of the bead) and parameters such as the bead\nsize and contour length of the molecule. We present both approximate analytic\nsolutions and numerical results for these effects in both flexible and\nsemiflexible tethers. Finally, our results give a precise,\nexperimentally-testable prediction for the probability distribution of the\ndistance between the polymer attachment point and the center of the mobile\nbead.",
    "arxiv_id": "q-bio/0508028",
    "authors": [
      "Darren E. Segall",
      "Phillip C. Nelson",
      "Rob Phillips"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "doi": "10.1103/PhysRevLett.96.088306",
    "journal_ref": "Phys. Rev. Lett. Vol 96, no. 088306 (2006)",
    "title": "Excluded-Volume Effects in Tethered-Particle Experiments: Bead Size   Matters",
    "url": "https://arxiv.org/abs/q-bio/0508028"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "8bcb5bd0-c3a3-4ee6-856a-3f808faeabd7",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}