dorsal/arxiv
View SchemaExons, introns and DNA thermodynamics
| Authors | Enrico Carlon, Mehdi Lejard Malki, Ralf Blossey |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0409034 |
| URL | https://arxiv.org/abs/q-bio/0409034 |
| DOI | 10.1103/PhysRevLett.94.178101 |
| Journal | Phys. Rev. Lett. 94, 178101 (2005) |
Abstract
The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e. stretches of DNA which do not carry any useful information for the protein synthesis. We have analyzed the melting behavior of randomly selected human cDNA sequences obtained from the genomic DNA by removing all introns. A clear correspondence is observed between exons and melting domains. This finding may provide new insights in the physical mechanisms underlying the evolution of genes.
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"abstract": "The genes of eukaryotes are characterized by protein coding fragments, the\nexons, interrupted by introns, i.e. stretches of DNA which do not carry any\nuseful information for the protein synthesis. We have analyzed the melting\nbehavior of randomly selected human cDNA sequences obtained from the genomic\nDNA by removing all introns. A clear correspondence is observed between exons\nand melting domains. This finding may provide new insights in the physical\nmechanisms underlying the evolution of genes.",
"arxiv_id": "q-bio/0409034",
"authors": [
"Enrico Carlon",
"Mehdi Lejard Malki",
"Ralf Blossey"
],
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"q-bio.BM",
"cond-mat.stat-mech",
"physics.bio-ph"
],
"doi": "10.1103/PhysRevLett.94.178101",
"journal_ref": "Phys. Rev. Lett. 94, 178101 (2005)",
"title": "Exons, introns and DNA thermodynamics",
"url": "https://arxiv.org/abs/q-bio/0409034"
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