dorsal/arxiv
View SchemaExpression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
| Authors | T. Rozovskaia, O. Ravid-Amir, S. Tillib, G. Getz, E. Feinstein, H. Agrawal, A. Nagler, E. Rappeport, I. Issaeva, Y. Matsuo, U. R. Kees, T. Lapidot, F. Lo Coco, R. Foa, A. Mazo, T. Nakamura, C. M. Croce, G. Cimino, E. Domany, E. Canaani |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511016 |
| URL | https://arxiv.org/abs/q-bio/0511016 |
| DOI | 10.1073/pnas.1132115100 |
| Journal | PNAS vol 100, p 7853 (2003) |
Abstract
The ALL-1 gene is directly involved in 5-10% of ALLs and AMLs by fusion to other genes or through internal rearrangements. DNA microarrays were utilized to determine expression profiles of ALLs and AMLs with ALL-1 rearrangements. These profiles distinguish those tumors from other ALLs and AMLs. The expression patterns of ALL-1-associated tumors, in particular ALLs, involve oncogenes, tumor suppressors, anti apoptotic genes, drug resistance genes etc., and correlate with the aggressive nature of the tumors. The genes whose expression differentiates between ALLs with and without ALL-1 rearrangement were further divided into several groups enabling separation of ALL-1- associated ALLs into two subclasses. Further, AMLs with partial duplication of ALL-1 vary in their expression pattern from AMLs in which ALL-1 had undergone fusion to other genes. The extensive analysis described here draws attention to genes which might have a direct role in pathogenesis.
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"abstract": "The ALL-1 gene is directly involved in 5-10% of ALLs and AMLs by fusion to\nother genes or through internal rearrangements. DNA microarrays were utilized\nto determine expression profiles of ALLs and AMLs with ALL-1 rearrangements.\nThese profiles distinguish those tumors from other ALLs and AMLs. The\nexpression patterns of ALL-1-associated tumors, in particular ALLs, involve\noncogenes, tumor suppressors, anti apoptotic genes, drug resistance genes etc.,\nand correlate with the aggressive nature of the tumors. The genes whose\nexpression differentiates between ALLs with and without ALL-1 rearrangement\nwere further divided into several groups enabling separation of ALL-1-\nassociated ALLs into two subclasses. Further, AMLs with partial duplication of\nALL-1 vary in their expression pattern from AMLs in which ALL-1 had undergone\nfusion to other genes. The extensive analysis described here draws attention to\ngenes which might have a direct role in pathogenesis.",
"arxiv_id": "q-bio/0511016",
"authors": [
"T. Rozovskaia",
"O. Ravid-Amir",
"S. Tillib",
"G. Getz",
"E. Feinstein",
"H. Agrawal",
"A. Nagler",
"E. Rappeport",
"I. Issaeva",
"Y. Matsuo",
"U. R. Kees",
"T. Lapidot",
"F. Lo Coco",
"R. Foa",
"A. Mazo",
"T. Nakamura",
"C. M. Croce",
"G. Cimino",
"E. Domany",
"E. Canaani"
],
"categories": [
"q-bio.QM",
"q-bio.OT"
],
"doi": "10.1073/pnas.1132115100",
"journal_ref": "PNAS vol 100, p 7853 (2003)",
"title": "Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements",
"url": "https://arxiv.org/abs/q-bio/0511016"
},
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