{
  "annotation_id": "dd39282f-1e44-440f-af14-48421bc5acbe",
  "date_created": "2026-03-02T18:01:31.419000Z",
  "date_modified": "2026-03-02T18:01:31.419000Z",
  "file_hash": "2f51b139ddd978bf4a423e5641b9cb15fc8f8ffed21897e8228c6886ddda1e60",
  "private": false,
  "record": {
    "abstract": "A probability model is presented for the dynamics of mutation-selection\nbalance in a haploid infinite-population infinite-sites setting sufficiently\ngeneral to cover mutation-driven changes in full age-specific demographic\nschedules. The model accommodates epistatic as well as additive selective\ncosts. Closed form characterizations are obtained for solutions in finite time,\nalong with proofs of convergence to stationary distributions and a proof of the\nuniqueness of solutions in a restricted case. Examples are given of\napplications to the biodemography of aging, including instabilities in current\nformulations of mutation accumulation.",
    "arxiv_id": "q-bio/0403002",
    "authors": [
      "David Steinsaltz",
      "Steven N. Evans",
      "Kenneth W. Wachter"
    ],
    "categories": [
      "q-bio.PE",
      "math.PR"
    ],
    "title": "A generalized model of mutation-selection balance with applications to   aging",
    "url": "https://arxiv.org/abs/q-bio/0403002"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "64dbed6f-e9d5-4926-83bc-9d0af755a8f8",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}