dorsal/arxiv
View SchemaA generalized model of mutation-selection balance with applications to aging
| Authors | David Steinsaltz, Steven N. Evans, Kenneth W. Wachter |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0403002 |
| URL | https://arxiv.org/abs/q-bio/0403002 |
Abstract
A probability model is presented for the dynamics of mutation-selection balance in a haploid infinite-population infinite-sites setting sufficiently general to cover mutation-driven changes in full age-specific demographic schedules. The model accommodates epistatic as well as additive selective costs. Closed form characterizations are obtained for solutions in finite time, along with proofs of convergence to stationary distributions and a proof of the uniqueness of solutions in a restricted case. Examples are given of applications to the biodemography of aging, including instabilities in current formulations of mutation accumulation.
{
"annotation_id": "dd39282f-1e44-440f-af14-48421bc5acbe",
"date_created": "2026-03-02T18:01:31.419000Z",
"date_modified": "2026-03-02T18:01:31.419000Z",
"file_hash": "2f51b139ddd978bf4a423e5641b9cb15fc8f8ffed21897e8228c6886ddda1e60",
"private": false,
"record": {
"abstract": "A probability model is presented for the dynamics of mutation-selection\nbalance in a haploid infinite-population infinite-sites setting sufficiently\ngeneral to cover mutation-driven changes in full age-specific demographic\nschedules. The model accommodates epistatic as well as additive selective\ncosts. Closed form characterizations are obtained for solutions in finite time,\nalong with proofs of convergence to stationary distributions and a proof of the\nuniqueness of solutions in a restricted case. Examples are given of\napplications to the biodemography of aging, including instabilities in current\nformulations of mutation accumulation.",
"arxiv_id": "q-bio/0403002",
"authors": [
"David Steinsaltz",
"Steven N. Evans",
"Kenneth W. Wachter"
],
"categories": [
"q-bio.PE",
"math.PR"
],
"title": "A generalized model of mutation-selection balance with applications to aging",
"url": "https://arxiv.org/abs/q-bio/0403002"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "64dbed6f-e9d5-4926-83bc-9d0af755a8f8",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}