dorsal/arxiv
View SchemaNew structural variation in evolutionary searches of RNA neutral networks
| Authors | Sumedha, Olivier C Martin, Andreas Wagner |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0612028 |
| URL | https://arxiv.org/abs/q-bio/0612028 |
| Journal | Biosystems 90, 475-485(2007) |
Abstract
RNA secondary structure is an important computational model to understand how genetic variation maps into phenotypic (structural) variation. Evolutionary innovation in RNA structures is facilitated by neutral networks, large connected sets of RNA sequences that fold into the same structure. Our work extends and deepens previous studies on neutral networks. First, we show that even the 1-mutant neighborhood of a given sequence (genotype) G0 with structure (phenotype) P contains many structural variants that are not close to P. This holds for biological and generic RNA sequences alike. Second, we analyze the relation between new structures in the 1-neighborhoods of genotypes Gk that are only a moderate Hamming distance k away from G0, and the structure of G0 itself, both for biological and for generic RNA structures. Third, we analyze the relation between mutational robustness of a sequence and the distances of structural variants near this sequence. Our findings underscore the role of neutral networks in evolutionary innovation, and the role that high robustness can play in diminishing the potential for such innovation.
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"abstract": "RNA secondary structure is an important computational model to understand how\ngenetic variation maps into phenotypic (structural) variation. Evolutionary\ninnovation in RNA structures is facilitated by neutral networks, large\nconnected sets of RNA sequences that fold into the same structure. Our work\nextends and deepens previous studies on neutral networks. First, we show that\neven the 1-mutant neighborhood of a given sequence (genotype) G0 with structure\n(phenotype) P contains many structural variants that are not close to P. This\nholds for biological and generic RNA sequences alike. Second, we analyze the\nrelation between new structures in the 1-neighborhoods of genotypes Gk that are\nonly a moderate Hamming distance k away from G0, and the structure of G0\nitself, both for biological and for generic RNA structures. Third, we analyze\nthe relation between mutational robustness of a sequence and the distances of\nstructural variants near this sequence. Our findings underscore the role of\nneutral networks in evolutionary innovation, and the role that high robustness\ncan play in diminishing the potential for such innovation.",
"arxiv_id": "q-bio/0612028",
"authors": [
"Sumedha",
"Olivier C Martin",
"Andreas Wagner"
],
"categories": [
"q-bio.PE"
],
"journal_ref": "Biosystems 90, 475-485(2007)",
"title": "New structural variation in evolutionary searches of RNA neutral networks",
"url": "https://arxiv.org/abs/q-bio/0612028"
},
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