dorsal/arxiv
View SchemaThermal unfolding of proteins
| Authors | Marek Cieplak, Joanna I. Sulkowska |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0601049 |
| URL | https://arxiv.org/abs/q-bio/0601049 |
| DOI | 10.1063/1.2121668 |
| Journal | J. Chem. Phys. 123, 194908 (2005) |
Abstract
Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature, contacts break at separate time scales and unfolding proceeds approximately in a way reverse to folding. Features in these scenarios agree with experiments and atomic simulations on titin.
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"abstract": "Thermal unfolding of proteins is compared to folding and mechanical\nstretching in a simple topology-based dynamical model. We define the unfolding\ntime and demonstrate its low-temperature divergence. Below a characteristic\ntemperature, contacts break at separate time scales and unfolding proceeds\napproximately in a way reverse to folding. Features in these scenarios agree\nwith experiments and atomic simulations on titin.",
"arxiv_id": "q-bio/0601049",
"authors": [
"Marek Cieplak",
"Joanna I. Sulkowska"
],
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"doi": "10.1063/1.2121668",
"journal_ref": "J. Chem. Phys. 123, 194908 (2005)",
"title": "Thermal unfolding of proteins",
"url": "https://arxiv.org/abs/q-bio/0601049"
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