dorsal/arxiv
View SchemaRecycling probability and dynamical properties of germinal center reactions
| Authors | Michael Meyer-Hermann, Andreas Deutsch, Michal Or-Guil |
|---|---|
| Categories | |
| ArXiv ID | physics/0101015 |
| URL | https://arxiv.org/abs/physics/0101015 |
| Journal | J. Theor. Biol. 210(3) 2001, 265-285 |
Abstract
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han et al. (1995b) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns out to be necessary for the optimization process during the germinal center reaction. The dependence of the germinal center reaction on the recycling probability is analyzed.
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"abstract": "We introduce a new model for the dynamics of centroblasts and centrocytes in\na germinal center. The model reduces the germinal center reaction to the\nelements considered as essential and embeds proliferation of centroblasts,\npoint mutations of the corresponding antibody types represented in a shape\nspace, differentiation to centrocytes, selection with respect to initial\nantigens, differentiation of positively selected centrocytes to plasma or\nmemory cells and recycling of centrocytes to centroblasts. We use exclusively\nparameters with a direct biological interpretation such that, once determined\nby experimental data, the model gains predictive power. Based on the experiment\nof Han et al. (1995b) we predict that a high rate of recycling of centrocytes\nto centroblasts is necessary for the germinal center reaction to work reliably.\nFurthermore, we find a delayed start of the production of plasma and memory\ncells with respect to the start of point mutations, which turns out to be\nnecessary for the optimization process during the germinal center reaction. The\ndependence of the germinal center reaction on the recycling probability is\nanalyzed.",
"arxiv_id": "physics/0101015",
"authors": [
"Michael Meyer-Hermann",
"Andreas Deutsch",
"Michal Or-Guil"
],
"categories": [
"physics.bio-ph",
"q-bio.CB"
],
"journal_ref": "J. Theor. Biol. 210(3) 2001, 265-285",
"title": "Recycling probability and dynamical properties of germinal center reactions",
"url": "https://arxiv.org/abs/physics/0101015"
},
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