dorsal/arxiv
View SchemaSpecific protein-protein binding in many-component mixtures of proteins
| Authors | Richard P. Sear |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0312033 |
| URL | https://arxiv.org/abs/q-bio/0312033 |
| DOI | 10.1088/1478-3967/1/2/001 |
| Journal | Physical Biology v1, 53 (2004) |
Abstract
Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically present in vivo. Using a simple model of a protein, specific binding in many component mixtures is studied. It is found to be a demanding function in the sense that it demands that the binding sites of the proteins be encoded by long sequences of bits, and the requirement for specific binding then strongly constrains these sequences. This is quantified by the capacity of proteins of a given size (sequence length), which is the maximum number of specific-binding interactions possible in a mixture. This calculation of the maximum number possible is in the same spirit as the work of Shannon and others on the maximum rate of communication through noisy channels.
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"abstract": "Proteins must bind to specific other proteins in vivo in order to function.\nThe proteins must bind only to one or a few other proteins of the of order a\nthousand proteins typically present in vivo. Using a simple model of a protein,\nspecific binding in many component mixtures is studied. It is found to be a\ndemanding function in the sense that it demands that the binding sites of the\nproteins be encoded by long sequences of bits, and the requirement for specific\nbinding then strongly constrains these sequences. This is quantified by the\ncapacity of proteins of a given size (sequence length), which is the maximum\nnumber of specific-binding interactions possible in a mixture. This calculation\nof the maximum number possible is in the same spirit as the work of Shannon and\nothers on the maximum rate of communication through noisy channels.",
"arxiv_id": "q-bio/0312033",
"authors": [
"Richard P. Sear"
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"doi": "10.1088/1478-3967/1/2/001",
"journal_ref": "Physical Biology v1, 53 (2004)",
"title": "Specific protein-protein binding in many-component mixtures of proteins",
"url": "https://arxiv.org/abs/q-bio/0312033"
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