dorsal/arxiv
View SchemaDynamics and pattern formation in invasive tumor growth
| Authors | Evgeniy Khain, Leonard M. Sander |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0507034 |
| URL | https://arxiv.org/abs/q-bio/0507034 |
| DOI | 10.1103/PhysRevLett.96.188103 |
Abstract
In this work, we study the in-vitro dynamics of the most malignant form of the primary brain tumor: Glioblastoma Multiforme. Typically, the growing tumor consists of the inner dense proliferating zone and the outer less dense invasive region. Experiments with different types of cells show qualitatively different behavior. Wild-type cells invade a spherically symmetric manner, but mutant cells are organized in tenuous branches. We formulate a model for this sort of growth using two coupled reaction-diffusion equations for the cell and nutrient concentrations. When the ratio of the nutrient and cell diffusion coefficients exceeds some critical value, the plane propagating front becomes unstable with respect to transversal perturbations. The instability threshold and the full phase-plane diagram in the parameter space are determined. The results are in a good agreement with experimental findings for the two types of cells.
{
"annotation_id": "d7b7d7a1-3846-45a0-a20d-2d2219dbbea2",
"date_created": "2026-03-02T18:01:31.799000Z",
"date_modified": "2026-03-02T18:01:31.799000Z",
"file_hash": "1369ecd7fbfdc416848b7bea63ec6244074b17f3b5e04b20dd3e392249045e8f",
"private": false,
"record": {
"abstract": "In this work, we study the in-vitro dynamics of the most malignant form of\nthe primary brain tumor: Glioblastoma Multiforme. Typically, the growing tumor\nconsists of the inner dense proliferating zone and the outer less dense\ninvasive region. Experiments with different types of cells show qualitatively\ndifferent behavior. Wild-type cells invade a spherically symmetric manner, but\nmutant cells are organized in tenuous branches. We formulate a model for this\nsort of growth using two coupled reaction-diffusion equations for the cell and\nnutrient concentrations. When the ratio of the nutrient and cell diffusion\ncoefficients exceeds some critical value, the plane propagating front becomes\nunstable with respect to transversal perturbations. The instability threshold\nand the full phase-plane diagram in the parameter space are determined. The\nresults are in a good agreement with experimental findings for the two types of\ncells.",
"arxiv_id": "q-bio/0507034",
"authors": [
"Evgeniy Khain",
"Leonard M. Sander"
],
"categories": [
"q-bio.CB"
],
"doi": "10.1103/PhysRevLett.96.188103",
"title": "Dynamics and pattern formation in invasive tumor growth",
"url": "https://arxiv.org/abs/q-bio/0507034"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "2ee3326f-cf3e-487c-af68-6b8e4607cab1",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}