dorsal/arxiv
View SchemaDetermination of barrier heights and prefactors from protein folding rate data
| Authors | Steven S. Plotkin |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0502011 |
| URL | https://arxiv.org/abs/q-bio/0502011 |
| DOI | 10.1529/biophysj.104.052548 |
Abstract
We determine both barrier heights and prefactors for protein folding by applying constraints determined from experimental rate measurements to a Kramers theory for folding rate. The theoretical values are required to match the experimental values at two conditions of temperature and denaturant that induce the same stability. Several expressions for the prefactor in the Kramers rate equation are examined: a random energy approximation, a correlated energy approximation, and an approximation using a single Arrhenius activation energy. Barriers and prefactors are generally found to be large as a result of implementing this recipe, i.e. the folding landscape is cooperative and smooth. Interestingly, a prefactor with a single Arrhenius activation energy admits no formal solution.
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"abstract": "We determine both barrier heights and prefactors for protein folding by\napplying constraints determined from experimental rate measurements to a\nKramers theory for folding rate. The theoretical values are required to match\nthe experimental values at two conditions of temperature and denaturant that\ninduce the same stability. Several expressions for the prefactor in the Kramers\nrate equation are examined: a random energy approximation, a correlated energy\napproximation, and an approximation using a single Arrhenius activation energy.\nBarriers and prefactors are generally found to be large as a result of\nimplementing this recipe, i.e. the folding landscape is cooperative and smooth.\nInterestingly, a prefactor with a single Arrhenius activation energy admits no\nformal solution.",
"arxiv_id": "q-bio/0502011",
"authors": [
"Steven S. Plotkin"
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"doi": "10.1529/biophysj.104.052548",
"title": "Determination of barrier heights and prefactors from protein folding rate data",
"url": "https://arxiv.org/abs/q-bio/0502011"
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