dorsal/arxiv
View SchemaModeling DNA Conformational Transformations on the Mesoscopic Scales
| Authors | S. N. Volkov |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0312034 |
| URL | https://arxiv.org/abs/q-bio/0312034 |
| Journal | Biophys. Bulletin (Visnyk Kharkiv university) 2(7) (2000) 7-15; 1(12) (2003) 5-12 |
Abstract
The approach for the description of the DNA conformational transformations on the mesoscopic scales in the frame of the double helix is presented. Due to consideration of the joint motions of DNA structural elements along the conformational pathways the models for different transformations may be constructed in the unifying two-component form. One component of the model is the degree of freedom of the elastic rod and another component -- the effective coordinate of the conformational transformation. The internal and external model components are interrelated, as it is characteristic for the DNA structure organization. It is shown that the kinetic energy of the conformational transformation of heterogeneous DNA may be put in homogeneous form. In the frame of the developed approach the static excitations of the DNA structure under the transitions between the stable states are found for internal and external components. The comparison of the data obtained with the experiment on intrinsic DNA deformability shows good qualitative agreement. The conclusion is made that the found excitations in the DNA structure may be classificated as the static conformational solitons.
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"abstract": "The approach for the description of the DNA conformational transformations on\nthe mesoscopic scales in the frame of the double helix is presented. Due to\nconsideration of the joint motions of DNA structural elements along the\nconformational pathways the models for different transformations may be\nconstructed in the unifying two-component form. One component of the model is\nthe degree of freedom of the elastic rod and another component -- the effective\ncoordinate of the conformational transformation. The internal and external\nmodel components are interrelated, as it is characteristic for the DNA\nstructure organization. It is shown that the kinetic energy of the\nconformational transformation of heterogeneous DNA may be put in homogeneous\nform. In the frame of the developed approach the static excitations of the DNA\nstructure under the transitions between the stable states are found for\ninternal and external components. The comparison of the data obtained with the\nexperiment on intrinsic DNA deformability shows good qualitative agreement. The\nconclusion is made that the found excitations in the DNA structure may be\nclassificated as the static conformational solitons.",
"arxiv_id": "q-bio/0312034",
"authors": [
"S. N. Volkov"
],
"categories": [
"q-bio.BM"
],
"journal_ref": "Biophys. Bulletin (Visnyk Kharkiv university) 2(7) (2000) 7-15;\n 1(12) (2003) 5-12",
"title": "Modeling DNA Conformational Transformations on the Mesoscopic Scales",
"url": "https://arxiv.org/abs/q-bio/0312034"
},
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