{
  "annotation_id": "d647ed43-5c77-451f-ac2e-8618f8a88e14",
  "date_created": "2026-03-02T18:01:35.710000Z",
  "date_modified": "2026-03-02T18:01:35.710000Z",
  "file_hash": "5ce5741d6f52eb58f44c20c751a4223dc649d92ce2c417b3520d6cb90a9d23bc",
  "private": false,
  "record": {
    "abstract": "We build a model for the hepatic fatty acid metabolism and its metabolic and\ngenetic regulations. The model has two functioning modes: synthesis and\noxidation of fatty acids. We provide a sufficient condition (the strong\nlipolytic condition) for the uniqueness of its equilibrium. Under this\ncondition, modifications of the glucose input produce equilibrium shifts, which\nare gradual changes from one functioning mode to the other. We also discuss the\nconcentration variations of various metabolites during equilibrium shifts. The\nmodel can explain a certain amount of experimental observations, assess the\nrole of poly-unsaturated fatty acids in genetic regulation, and predict the\nbehavior of mutants. The analysis of the model is based on block elimination of\nvariables and uses a modular decomposition of the system dictated by\nmathematical global univalence conditions.",
    "arxiv_id": "q-bio/0603021",
    "authors": [
      "O. Radulescu",
      "A. Siegel",
      "E. Pecou",
      "S. Lagarrigue"
    ],
    "categories": [
      "q-bio.CB"
    ],
    "title": "A model for regulated fatty acid metabolism in liver; equilibria and   their changes",
    "url": "https://arxiv.org/abs/q-bio/0603021"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "ec4e35f1-447c-4eab-a390-9928a2323582",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}