dorsal/arxiv
View SchemaLarge phenotype jumps in biomolecular evolution
| Authors | F. Bardou, L. Jaeger |
|---|---|
| Categories | |
| ArXiv ID | physics/0310157 |
| URL | https://arxiv.org/abs/physics/0310157 |
| DOI | 10.1103/PhysRevE.69.031908 |
| Journal | Phys. Rev. E 69 (2004) 031908.1-7 |
Abstract
By defining the phenotype of a biopolymer by its active three-dimensional shape, and its genotype by its primary sequence, we propose a model that predicts and characterizes the statistical distribution of a population of biopolymers with a specific phenotype, that originated from a given genotypic sequence by a single mutational event. Depending on the ratio g0 that characterizes the spread of potential energies of the mutated population with respect to temperature, three different statistical regimes have been identified. We suggest that biopolymers found in nature are in a critical regime with g0 in the range 1-6, corresponding to a broad, but not too broad, phenotypic distribution resembling a truncated Levy flight. Thus the biopolymer phenotype can be considerably modified in just a few mutations. The proposed model is in good agreement with the experimental distribution of activities determined for a population of single mutants of a group I ribozyme.
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"abstract": "By defining the phenotype of a biopolymer by its active three-dimensional\nshape, and its genotype by its primary sequence, we propose a model that\npredicts and characterizes the statistical distribution of a population of\nbiopolymers with a specific phenotype, that originated from a given genotypic\nsequence by a single mutational event. Depending on the ratio g0 that\ncharacterizes the spread of potential energies of the mutated population with\nrespect to temperature, three different statistical regimes have been\nidentified. We suggest that biopolymers found in nature are in a critical\nregime with g0 in the range 1-6, corresponding to a broad, but not too broad,\nphenotypic distribution resembling a truncated Levy flight. Thus the biopolymer\nphenotype can be considerably modified in just a few mutations. The proposed\nmodel is in good agreement with the experimental distribution of activities\ndetermined for a population of single mutants of a group I ribozyme.",
"arxiv_id": "physics/0310157",
"authors": [
"F. Bardou",
"L. Jaeger"
],
"categories": [
"physics.bio-ph",
"cond-mat.soft",
"physics.data-an",
"q-bio.PE"
],
"doi": "10.1103/PhysRevE.69.031908",
"journal_ref": "Phys. Rev. E 69 (2004) 031908.1-7",
"title": "Large phenotype jumps in biomolecular evolution",
"url": "https://arxiv.org/abs/physics/0310157"
},
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