{
  "annotation_id": "d41cac8f-8628-42f3-a9a5-5b055386dac3",
  "date_created": "2026-03-02T18:01:28.761000Z",
  "date_modified": "2026-03-02T18:01:28.761000Z",
  "file_hash": "201d16a6890a5df2e08b37c421f90b8accc96bfe8c6fd10a6bd043cd75952516",
  "private": false,
  "record": {
    "abstract": "We study genetic switches formed from pairs of mutually repressing operons.\nThe switch stability is characterised by a well defined lifetime which grows\nsub-exponentially with the number of copies of the most-expressed transcription\nfactor, in the regime accessible by our numerical simulations. The stability\ncan be markedly enhanced by a suitable choice of overlap between the upstream\nregulatory domains. Our results suggest that robustness against biochemical\nnoise can provide a selection pressure that drives operons, that regulate each\nother, together in the course of evolution.",
    "arxiv_id": "q-bio/0310041",
    "authors": [
      "Patrick B. Warren",
      "Pieter Rein ten Wolde"
    ],
    "categories": [
      "q-bio.MN"
    ],
    "doi": "10.1103/PhysRevLett.92.128101",
    "title": "Enhancement of the stability of genetic switches by overlapping upstream   regulatory domains",
    "url": "https://arxiv.org/abs/q-bio/0310041"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "779459f3-9c97-45d6-8a4a-8bf058e3f8d5",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}