dorsal/arxiv
View SchemaDistributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4
| Authors | Igor Pshenichnov, Igor Mishustin, Walter Greiner |
|---|---|
| Categories | |
| ArXiv ID | physics/0608017 |
| URL | https://arxiv.org/abs/physics/0608017 |
| DOI | 10.1088/0031-9155/51/23/011 |
| Journal | Phys. Med. Biol. 51 (2006) 6099-6112 |
Abstract
Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of $^{11}$C, $^{10}$C and $^{15}$O nuclei are compared with experimental data and with corresponding results of the FLUKA and POSGEN codes. The distributions of e$^+$ annihilation points are obtained by simulating radioactive decay of unstable nuclei and transporting positrons in surrounding medium. A finite spatial resolution of the Positron Emission Tomography (PET) is taken into account in a simplified way. Depth distributions of $\beta^+$-activity as seen by a PET scanner are calculated and compared to available data for PMMA phantoms. The calculated $\beta^+$-activity profiles are in good agreement with PET data for proton and $^{12}$C beams at energies suitable for particle therapy. The MCHIT capability to predict the $\beta^+$-activity and dose distributions in tissue-like materials of different chemical composition is demonstrated.
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"abstract": "Depth distributions of positron-emitting nuclei in PMMA phantoms are\ncalculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on\nthe GEANT4 toolkit (version 8.0). The calculated total production rates of\n$^{11}$C, $^{10}$C and $^{15}$O nuclei are compared with experimental data and\nwith corresponding results of the FLUKA and POSGEN codes. The distributions of\ne$^+$ annihilation points are obtained by simulating radioactive decay of\nunstable nuclei and transporting positrons in surrounding medium. A finite\nspatial resolution of the Positron Emission Tomography (PET) is taken into\naccount in a simplified way. Depth distributions of $\\beta^+$-activity as seen\nby a PET scanner are calculated and compared to available data for PMMA\nphantoms. The calculated $\\beta^+$-activity profiles are in good agreement with\nPET data for proton and $^{12}$C beams at energies suitable for particle\ntherapy. The MCHIT capability to predict the $\\beta^+$-activity and dose\ndistributions in tissue-like materials of different chemical composition is\ndemonstrated.",
"arxiv_id": "physics/0608017",
"authors": [
"Igor Pshenichnov",
"Igor Mishustin",
"Walter Greiner"
],
"categories": [
"physics.med-ph"
],
"doi": "10.1088/0031-9155/51/23/011",
"journal_ref": "Phys. Med. Biol. 51 (2006) 6099-6112",
"title": "Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4",
"url": "https://arxiv.org/abs/physics/0608017"
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