dorsal/arxiv
View SchemaA model for the accidental catalysis of protein unfolding in vivo
| Authors | Richard P. Sear |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0409025 |
| URL | https://arxiv.org/abs/q-bio/0409025 |
| DOI | 10.1209/epl/i2004-10249-7 |
Abstract
Activated processes such as protein unfolding are highly sensitive to heterogeneity in the environment. We study a highly simplified model of a protein in a random heterogeneous environment, a model of the in vivo environment. It is found that if the heterogeneity is sufficiently large the total rate of the process is essentially a random variable; this may be the cause of the species-to-species variability in the rate of prion protein conversion found by Deleault et al. [Nature, 425 (2003) 717].
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"abstract": "Activated processes such as protein unfolding are highly sensitive to\nheterogeneity in the environment. We study a highly simplified model of a\nprotein in a random heterogeneous environment, a model of the in vivo\nenvironment. It is found that if the heterogeneity is sufficiently large the\ntotal rate of the process is essentially a random variable; this may be the\ncause of the species-to-species variability in the rate of prion protein\nconversion found by Deleault et al. [Nature, 425 (2003) 717].",
"arxiv_id": "q-bio/0409025",
"authors": [
"Richard P. Sear"
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"doi": "10.1209/epl/i2004-10249-7",
"title": "A model for the accidental catalysis of protein unfolding in vivo",
"url": "https://arxiv.org/abs/q-bio/0409025"
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