{
  "annotation_id": "d3865907-e7f9-4a1e-b973-429d4400e2a3",
  "date_created": "2026-03-02T18:01:32.239000Z",
  "date_modified": "2026-03-02T18:01:32.239000Z",
  "file_hash": "600dbe21d37b376d5e2303bd15c008ffe6416a582cbebd081aaa8499823f7c9f",
  "private": false,
  "record": {
    "abstract": "Activated processes such as protein unfolding are highly sensitive to\nheterogeneity in the environment. We study a highly simplified model of a\nprotein in a random heterogeneous environment, a model of the in vivo\nenvironment. It is found that if the heterogeneity is sufficiently large the\ntotal rate of the process is essentially a random variable; this may be the\ncause of the species-to-species variability in the rate of prion protein\nconversion found by Deleault et al. [Nature, 425 (2003) 717].",
    "arxiv_id": "q-bio/0409025",
    "authors": [
      "Richard P. Sear"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "doi": "10.1209/epl/i2004-10249-7",
    "title": "A model for the accidental catalysis of protein unfolding in vivo",
    "url": "https://arxiv.org/abs/q-bio/0409025"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "15e4a728-e0a3-425f-b42a-8bfd52bc91b1",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}