dorsal/arxiv
View SchemaPreliminary study of metabolic radiotherapy with 188Re via small animal imaging
| Authors | G. Baldazzi, D. Bollini, A. Muciaccio, F. -L. Navarria, G. Pancaldi, A. Perrotta, M. Zuffa, P. Boccaccio, N. Uzunov, M. Bello, D. Bernardini, U. Mazzi, G. Moschini, M. Riondato, A. Rosato, F. Garibaldi, R. Pani, A. Antoccia, F. de Notaristefani, G. Hull, V. Orsolini Cencelli, A. Sgura, C. Tanzarella |
|---|---|
| Categories | |
| ArXiv ID | physics/0506008 |
| URL | https://arxiv.org/abs/physics/0506008 |
Abstract
188Re is a beta- (Emax = 2.12 MeV) and gamma (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, 99mTc, molecules of hyaluronic acid (HA) have been labelled with 188Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm**3 pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of 188Re and with C57 black mice injected with the 188Re-HA solution are presented. To increase the space resolution and to obtain two orthogonal projections simultaneously we are building in parallel two new cameras to be positioned at 90 degrees. They use a CsI(Tl) matrix with 1x1x5 mm**3 pixels read out by H8500 Hamamatsu Flat panel PMT.
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"abstract": "188Re is a beta- (Emax = 2.12 MeV) and gamma (155 keV) emitter. Since its\nchemistry is similar to that of the largely employed tracer, 99mTc, molecules\nof hyaluronic acid (HA) have been labelled with 188Re to produce a target\nspecific radiopharmaceutical. The radiolabeled compound, i.v. injected in\nhealthy mice, is able to accumulate into the liver after a few minutes. To\nstudy the effect of metabolic radiotherapy in mice, we have built a small gamma\ncamera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm**3 pixels, read\nout by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead\nparallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is\nplaced in front of the YAP matrix. Preliminary results obtained with various\nphantoms containing a solution of 188Re and with C57 black mice injected with\nthe 188Re-HA solution are presented. To increase the space resolution and to\nobtain two orthogonal projections simultaneously we are building in parallel\ntwo new cameras to be positioned at 90 degrees. They use a CsI(Tl) matrix with\n1x1x5 mm**3 pixels read out by H8500 Hamamatsu Flat panel PMT.",
"arxiv_id": "physics/0506008",
"authors": [
"G. Baldazzi",
"D. Bollini",
"A. Muciaccio",
"F. -L. Navarria",
"G. Pancaldi",
"A. Perrotta",
"M. Zuffa",
"P. Boccaccio",
"N. Uzunov",
"M. Bello",
"D. Bernardini",
"U. Mazzi",
"G. Moschini",
"M. Riondato",
"A. Rosato",
"F. Garibaldi",
"R. Pani",
"A. Antoccia",
"F. de Notaristefani",
"G. Hull",
"V. Orsolini Cencelli",
"A. Sgura",
"C. Tanzarella"
],
"categories": [
"physics.med-ph"
],
"title": "Preliminary study of metabolic radiotherapy with 188Re via small animal imaging",
"url": "https://arxiv.org/abs/physics/0506008"
},
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