dorsal/arxiv
View SchemaThe stochastic entry of enveloped viruses: Fusion vs. endocytosis
| Authors | Tom Chou |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0703008 |
| URL | https://arxiv.org/abs/q-bio/0703008 |
| DOI | 10.1529/biophysj.107.106708 |
| Journal | Biophys. J., 93, 1116-1123, (2007) |
Abstract
Viral infection requires the binding of receptors on the target cell membrane to glycoproteins, or ``spikes,'' on the viral membrane. The initial entry is usually classified as fusogenic or endocytotic. However, binding of viral spikes to cell surface receptors not only initiates the viral adhesion and the wrapping process necessary for internalization, but can simultaneously initiate direct fusion with the cell membrane. Both fusion and internalization have been observed to be viable pathways for many viruses. We develop a stochastic model for viral entry that incorporates a competition between receptor mediated fusion and endocytosis. The relative probabilities of fusion and endocytosis of a virus particle initially nonspecifically adsorbed on the host cell membrane are computed as functions of receptor concentration, binding strength, and number of spikes. We find different parameter regimes where the entry pathway probabilities can be analytically expressed. Experimental tests of our mechanistic hypotheses are proposed and discussed.
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"abstract": "Viral infection requires the binding of receptors on the target cell membrane\nto glycoproteins, or ``spikes,\u0027\u0027 on the viral membrane. The initial entry is\nusually classified as fusogenic or endocytotic. However, binding of viral\nspikes to cell surface receptors not only initiates the viral adhesion and the\nwrapping process necessary for internalization, but can simultaneously initiate\ndirect fusion with the cell membrane. Both fusion and internalization have been\nobserved to be viable pathways for many viruses. We develop a stochastic model\nfor viral entry that incorporates a competition between receptor mediated\nfusion and endocytosis. The relative probabilities of fusion and endocytosis of\na virus particle initially nonspecifically adsorbed on the host cell membrane\nare computed as functions of receptor concentration, binding strength, and\nnumber of spikes. We find different parameter regimes where the entry pathway\nprobabilities can be analytically expressed. Experimental tests of our\nmechanistic hypotheses are proposed and discussed.",
"arxiv_id": "q-bio/0703008",
"authors": [
"Tom Chou"
],
"categories": [
"q-bio.SC"
],
"doi": "10.1529/biophysj.107.106708",
"journal_ref": "Biophys. J., 93, 1116-1123, (2007)",
"title": "The stochastic entry of enveloped viruses: Fusion vs. endocytosis",
"url": "https://arxiv.org/abs/q-bio/0703008"
},
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