dorsal/arxiv
View SchemaA Model for Predicting Magnetic Targeting of Multifunctional Particles in the Microvasculature
| Authors | E. J. Furlani, E. P. Furlani |
|---|---|
| Categories | |
| ArXiv ID | physics/0612116 |
| URL | https://arxiv.org/abs/physics/0612116 |
| DOI | 10.1016/j.jmmm.2006.09.026 |
Abstract
A mathematical model is presented for predicting magnetic targeting of multifunctional carrier particles that are designed to deliver therapeutic agents to malignant tissue in vivo. These particles consist of a nonmagnetic core material that contains embedded magnetic nanoparticles and therapeutic agents such as photodynamic sensitizers. For in vivo therapy, the particles are injected into the vascular system upstream from malignant tissue, and captured at the tumor using an applied magnetic field. The applied field couples to the magnetic nanoparticles inside the carrier particle and produces a force that attracts the particle to the tumor. In noninvasive therapy the applied field is produced by a permanent magnet positioned outside the body. In this paper a mathematical model is developed for predicting noninvasive magnetic targeting of therapeutic carrier particles in the microvasculature. The model takes into account the dominant magnetic and fluidic forces on the particles and leads to an analytical expression for predicting their trajectory. An analytical expression is also derived for predicting the volume fraction of embedded magnetic nanoparticles required to ensure capture of the carrier particle at the tumor. The model enables rapid parametric analysis of magnetic targeting as a function of key variables including the size of the carrier particle, the properties and volume fraction of the embedded magnetic nanoparticles, the properties of the magnet, the microvessel, the hematocrit of the blood and its flow rate.
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"abstract": "A mathematical model is presented for predicting magnetic targeting of\nmultifunctional carrier particles that are designed to deliver therapeutic\nagents to malignant tissue in vivo. These particles consist of a nonmagnetic\ncore material that contains embedded magnetic nanoparticles and therapeutic\nagents such as photodynamic sensitizers. For in vivo therapy, the particles are\ninjected into the vascular system upstream from malignant tissue, and captured\nat the tumor using an applied magnetic field. The applied field couples to the\nmagnetic nanoparticles inside the carrier particle and produces a force that\nattracts the particle to the tumor. In noninvasive therapy the applied field is\nproduced by a permanent magnet positioned outside the body. In this paper a\nmathematical model is developed for predicting noninvasive magnetic targeting\nof therapeutic carrier particles in the microvasculature. The model takes into\naccount the dominant magnetic and fluidic forces on the particles and leads to\nan analytical expression for predicting their trajectory. An analytical\nexpression is also derived for predicting the volume fraction of embedded\nmagnetic nanoparticles required to ensure capture of the carrier particle at\nthe tumor. The model enables rapid parametric analysis of magnetic targeting as\na function of key variables including the size of the carrier particle, the\nproperties and volume fraction of the embedded magnetic nanoparticles, the\nproperties of the magnet, the microvessel, the hematocrit of the blood and its\nflow rate.",
"arxiv_id": "physics/0612116",
"authors": [
"E. J. Furlani",
"E. P. Furlani"
],
"categories": [
"physics.bio-ph",
"physics.med-ph"
],
"doi": "10.1016/j.jmmm.2006.09.026",
"title": "A Model for Predicting Magnetic Targeting of Multifunctional Particles in the Microvasculature",
"url": "https://arxiv.org/abs/physics/0612116"
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